Effect of a Novel Stent on Re-Endothelialization, Platelet Adhesion, and Neointimal Formation

Journal of Atherosclerosis and Thrombosis
Hanfei TangMin Zhou

Abstract

Vascular endothelial-cadherin (VE-cadherin) is specifically expressed by outgrowth endothelial cells (OECs). Zwitterionic stent showed high antifouling and excellent blood compatibility. Therefore, we hypothesized that anti-VE-cadherin antibody-coated zwitterionic stents (VE-cad-Z stents) would promote re-endothelialization, reduce neointimal formation, and resist thrombus. VE-cad-Z stents were examined using platelet adhesion test, platelet activation, and OEC capture ability in vitro. In vivo effect of VE-cad-Z stents on re-endothelialization, thrombus-resistance, and neointima hyperplasia was investigated in left common carotid arteries of rabbits (n=15). In vitro, VE-cad-Z stents showed better platelet-resistance and OEC-capture ability (DNA concentration: 297.23±22.71 versus 67.49±15.26 ng/µL, P<0.01). In vivo, VE-cad-Z stents exhibited better patency rate than bare metal stents (BMS) (15/15 versus 12/15), and it significantly reduced platelet adhesion and neointima formation (neointima area: 1.13±0.05 versus 1.00±0.05mm(2), P<0.01 and 3.04±0.11versus 1.05±0.06mm(2), P<0.01, at 3 and 30 days, respectively; % stenosis: 20.99±0.98 versus 18.72±0.97, P<0.01 and 56.46±2.20 versus 19.45±1.24, P<0.01, at 3 and 30 days, respectiv...Continue Reading

References

Sep 1, 1992·The Journal of Cell Biology·M G LampugnaniE Dejana
Jul 15, 1997·The Journal of Clinical Investigation·J E FreedmanA D Michelson
Sep 5, 2002·Circulation·David SimperNoel M Caplice
Apr 1, 2003·Proceedings of the National Academy of Sciences of the United States of America·Noel M CapliceWilliam D Edwards
Aug 13, 2004·Cardiovascular Research·Andrew J CarterRobert Falotico
Jul 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Kwangmeyung KimYoungro Byun
May 28, 2010·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Marian BystroňPetr Widimský
Aug 3, 2010·Journal of Molecular and Cellular Cardiology·Matthew R Richardson, Mervin C Yoder
Nov 25, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Min ZhouChangjian Liu
Mar 20, 2013·BioMed Research International·Li ShenJunbo Ge
Nov 23, 2013·Journal of Biomaterials Applications·Xiaobo WangJian Shen
Oct 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaobo WangJian Shen

❮ Previous
Next ❯

Citations

Nov 10, 2015·Journal of Atherosclerosis and Thrombosis·Tetsuaki Hirase
Oct 26, 2018·Journal of Cellular and Molecular Medicine·Anne Cornelissen, Felix Jan Vogt
Mar 8, 2017·Journal of Cardiovascular Translational Research·Teresa Simon-YarzaDidier Letourneur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.