Effect of a nuclease-resistant derivative of polyriboinosinic-polyribocytidylic acid complex on yellow fever in rhesus monkeys (Macaca mulatta)

The Journal of Infectious Diseases
E L StephenH B Levy


Rhesus monkeys (Macaca mulatta) treated with a newly developed nuclease-resistant complex of polyriboinosinic-polyribocytidylic acid, poly-L-lysine, and carboxymethylcellulose [poly (ICLC)] did not die after challenge with virulent Asibi strain yellow fever (YF) virus. The strain of virus is sensitive to the effects of interferon in vitro and is lethal for rhesus monkeys four to six days after subcutaneous administration of 1,000 plaque-forming units of the virus. The mortality rate was reduced in monkeys initially treated 8 hr before or after inoculation of virus but was unchanged in monkeys initially treated 24 hr after challenge. Treated monkeys developed neutralizing antibody to YF virus. The successful treatment of yellow fever in a primate model with use of poly (ICLC) suggests a meaningful role for the interferon system in the host defense against this viral infection.


May 20, 2003·Immunology and Cell Biology·Michael S Diamond
Aug 22, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michael S Diamond
Aug 29, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Camila C DiasMarvin J Grubman
Sep 1, 1983·Antimicrobial Agents and Chemotherapy·J J KirsiR K Robins
Jan 11, 2000·Clinical Microbiology Reviews·P LeyssenJ Neyts
Mar 28, 2009·International Journal of Molecular Sciences·Mary E Christopher, Jonathan P Wong
Jan 1, 1981·Pharmacology & Therapeutics·E R Kern, L A Glasgow
Dec 7, 2007·Antiviral Research·T P Monath
May 14, 2005·Antiviral Chemistry & Chemotherapy·Michael Markosian, Robyn M Hyde
Dec 7, 2007·Antiviral Research·E A GouldJ S Mackenzie
Sep 1, 2004·The Lancet Infectious Diseases·Bruno P GranwehrAlan D T Barrett
Aug 25, 2005·Expert Review of Vaccines·T P Monath
Jun 16, 1992·Annals of the New York Academy of Sciences·M Kende
Nov 18, 2017·Biological Chemistry·Rebeca Froes RochaMauro Martins Teixeira
May 31, 2017·Seminars in Immunopathology·Christopher F Basler

Related Concepts

Antibodies, Viral
Interferon Inducers
Macaca mulatta
Poly I-C
Yellow Fever

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