Effect of a nutritional supplement on posaconazole pharmacokinetics following oral administration to healthy volunteers.

Antimicrobial Agents and Chemotherapy
Angela Sansone-ParsonsMarc A Saltzman

Abstract

We conducted a randomized, crossover study in healthy adults to examine the effects of a nutritional supplement (Boost Plus) on posaconazole pharmacokinetics. In this study, coadministration of posaconazole with Boost Plus increased the maximum concentration of posaconazole in serum and area under the concentration-time curve from 0 to 72 h values 3.4- and 2.6-fold, respectively, compared to those for the fasted state.

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