PMID: 2482729Aug 1, 1989Paper

Effect of a partial trisomy in the mouse upon cellular and nuclear RNA.

Biochemical Genetics
A V RakeM De Leon

Abstract

In a previous paper (Rake and Edwards, 1987) it was shown that the majority of the chromatin from trisomic mouse cells has nucleosomes with a smaller repeat length of DNA than the nucleosome repeat length of normal cells. Here it is shown that the RNA content of the total cell and of the nuclei is the same in all tissues studied, in both normal and trisomic cells. However, the amount per unit time or rate of RNA synthesis is depressed in the trisomic liver and brain nuclei. The depression of RNA synthesis could not be specified to the small trisomic section of the chromatin but instead must reflect the overall nuclear activity. These results, along with those of Devlin et al. (1988), indicate that the trisomic condition alters a substantial part of nuclear organization and activity, not just the small trisomic part.

References

May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D M Kurnit
Jul 14, 1968·Journal of Molecular Biology·J Paul, R S Gilmour
Sep 1, 1981·Analytical Biochemistry·L A BentleJ Metcoff
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J Klose, B Putz
Oct 1, 1962·Journal of Cellular and Comparative Physiology·A V RAKE, A F GRAHAM
Jul 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·R C HUANG, J BONNER
Jul 1, 1964·Biophysical Journal·A V RAKE, A F GRAHAM

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Citations

Jun 1, 1993·Biochemical Genetics·N H Kahmann, A V Rake
Aug 1, 1990·Biochemical Genetics·A V Rake

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