Effect of a plasma sodium biofeedback system applied to HFR on the intradialytic cardiovascular stability. Results from a randomized controlled study.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Francesco LocatelliCarlo Navino

Abstract

Intradialytic hypotension (IDH) is still a major clinical problem for haemodialysis (HD) patients. Haemodiafiltration (HDF) has been shown to be able to reduce the incidence of IDH. Fifty patients were enrolled in a prospective, randomized, crossover international study focussed on a variant of traditional HDF, haemofiltration with endogenous reinfusion (HFR). After a 1-month run-in period on HFR, the patients were randomized to two treatments of 2 months duration: HFR (Period A) or HFR-Aequilibrium (Period B), followed by a 1-month HFR wash-out period and then switched to the other treatment. HFR-Aequilibrium (HFR-Aeq) is an evolution of the haemofiltration with endogenous reinfusion (HFR) dialysis therapy, with dialysate sodium concentration and ultrafiltration rate profiles elaborated by an automated procedure. The primary end point was the frequency of IDH. Symptomatic hypotension episodes were significantly lower on HFR-Aeq versus HFR (23 ± 3 versus 31 ± 4% of sessions, respectively, P l= l0.03), as was the per cent of clinical interventions (17 ± 3% of sessions with almost one intervention on HFR-Aeq versus 22 ± 2% on HFR, P <0.01). In a post-hoc analysis, the effect of HFR-Aeq was greater on more unstable patients (35 ± ...Continue Reading

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Citations

Aug 21, 2013·Néphrologie & thérapeutique·Walid ArkoucheUNKNOWN les membres de la commission de dialyse de la Société de néphrologie
Jan 24, 2014·Seminars in Dialysis·Finnian R Mc Causland, Sushrut S Waikar
May 16, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Finnian R Mc Causland, Sushrut S Waikar
Jan 16, 2019·The Cochrane Database of Systematic Reviews·Joanna L DunlopMark R Marshall
Nov 1, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Susanne KronJoachim Kron
Jun 6, 2015·The International Journal of Artificial Organs·François GaillardThierry Petitclerc
Feb 6, 2017·Intensive Care Medicine·Lui G ForniMiet Schetz
Jun 17, 2021·Hemodialysis International·Lale A ErtugluMehmet Kanbay

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