Abstract
Recent research has established correlations between stress, anxiety, insomnia and excess body weight and these correlations have significant implications for health. This study measured the effects of a proprietary blend of extracts of Magnolia officinalis and Phellodendron amurense (Relora) on anxiety, stress and sleep in healthy premenopausal women. This randomized, parallel, placebo controlled clinical study was conducted with healthy, overweight (BMI 25 to 34.9), premenopausal female adults, between the ages of 20 and 50 years, who typically eat more in response to stressful situations and scores above the national mean for women on self-reporting anxiety. The intervention was Relora (250 mg capsules) or identical placebo 3 times daily for 6 weeks. Anxiety as measured by the Spielberger STATE-TRAIT questionnaires, salivary amylase and cortisol levels, Likert Scales/Visual Analog Scores for sleep quality and latency, appetite, and clinical markers of safety. The study was conducted by Miami Research Associates, a clinical research organization in Miami, FL. The intent-to-treat population consisted of 40 subjects with 26 participants completing the study. There were no significant adverse events. Relora was effective, in com...Continue Reading
References
Feb 14, 1998·Journal of Natural Products·Y MaruyamaS T Weintraub
Aug 28, 1998·The Journal of Pharmacy and Pharmacology·H KuribaraY Maruyama
Oct 6, 2000·Psychosomatic Medicine·E S EpelJ R Ickovics
Nov 9, 2000·Psychoneuroendocrinology·E EpelK Brownell
Feb 24, 2001·Psychopharmacology·K J SufkaL Zeng
Mar 27, 2004·Endocrinology·Mary F DallmanSusan F Akana
Sep 8, 2004·Life Sciences·Wen-Huang PengMing-Tsuen Hsieh
Dec 17, 2004·PLoS Medicine·Shahrad TaheriEmmanuel Mignot
Jun 7, 2005·Primary Care·Brian D Hoyt
Sep 7, 2007·Life Sciences·Wen-Huang PengYing-Chih Lin
Apr 23, 2008·Nutrition Journal·Douglas S KalmanRobert Garrison
Citations
Feb 26, 2013·CNS Drugs·Jerome SarrisDavid A Camfield
Aug 2, 2012·Journal of Biomedical Science·Jennifer Hui-Chun Ho, Chuang-Ye Hong
Aug 9, 2013·Journal of the International Society of Sports Nutrition·Shawn M TalbottMike Pugh
Mar 31, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Elham AlramadhanBenjamin S Weeks
Jul 4, 2009·World Journal of Gastroenterology : WJG·Shirin Hasani-RanjbarMohammad Abdollahi
Feb 24, 2016·Phytotherapy Research : PTR·Edwin Jothie RichardAmit Agarwal
Mar 27, 2012·Neuropharmacology·Mikhail AlexeevJanet L Fisher
Sep 11, 2014·Phytotherapy Research : PTR·Gregory P SwansonJoseph Basler
Feb 1, 2011·Pharmacology & Therapeutics·Young-Jung LeeJin Tae Hong
Mar 3, 2009·Psychoneuroendocrinology·U M Nater, N Rohleder
Oct 7, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Ram Chandra SaxenaKudiganti Venkateshwarlu
Mar 24, 2016·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Richella RyanAngela Clow
Oct 3, 2014·BioMed Research International·Radha S P MalonEmma P Córcoles
Apr 23, 2008·Nutrition Journal·Douglas S KalmanRobert Garrison
Sep 27, 2016·International Journal of Molecular Sciences·Xuezhong ZhaoYang Zheng
Mar 9, 2017·Journal of Zhejiang University. Science. B·Mélanie Poivre, Pierre Duez
Apr 9, 2016·Journal of Evidence-based Complementary & Alternative Medicine·Dnyanraj ChoudharyKedar Joshi
Aug 15, 2018·International Journal of Molecular Sciences·Abhishek Manoj RanawareAjaikumar B Kunnumakkara
Mar 18, 2020·Food Science & Nutrition·Lili XueRongrong Wu
Apr 28, 2020·Pilot and Feasibility Studies·Guowei LiLehana Thabane
Oct 20, 2020·Frontiers in Pharmacology·Dâmaris SilveiraMichael Heinrich
Jan 8, 2021·Chemistry & Biodiversity·Karol JędrejkoBożena Muszyńska
Sep 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Julia FedotovaPeter Kruzliak
Jul 13, 2021·Chinese Journal of Natural Medicines·Cheng ChenLi-Gen Lin