Effect of a reduction in blood viscosity on maximal myocardial oxygen delivery distal to a moderate coronary stenosis

Circulation
A S MostH Gewirtz

Abstract

This study tested the hypothesis that a reduction in blood viscosity by means of isovolumetric hemodilution will permit an increase in maximal oxygen delivery to myocardium distal to a moderate coronary arterial stenosis. It is known that blood viscosity is a determinant of resistance to blood flow at both the stenotic and the arteriolar levels. Accordingly, a reduction in blood viscosity could exert a favorable influence on maximal myocardial oxygen delivery in the setting of stenosis, provided that the oxygen-carrying capacity of the blood is not compromised excessively. Closed-chest, sedated domestic swine (n = 8) were instrumented with an artificial coronary arterial stenosis that reduced vessel diameter by 64%. Measurements of hemodynamics, regional myocardial blood flow (microspheres), lactate and oxygen metabolism, and whole blood viscosity were made at control and after two successive 10 min intracoronary infusions of adenosine (400 and 800 micrograms/min) distal to the stenosis. Next, albumin/saline solution was given intravenously to reduce the animal's hematocrit by approximately 50%. Repeat measurements of all experimental variables were then made at a second control and again after two successive 10 min intracorona...Continue Reading

References

Mar 1, 1978·Anesthesia and Analgesia·R J Gordon, M B Ravin
Oct 1, 1978·Circulation Research·A SurjadhanaJ I Hoffman
Sep 1, 1978·World Journal of Surgery·A S Geha, A E Baue
Jul 1, 1977·The American Journal of Physiology·K M Jan, S Chien
Sep 1, 1965·Diseases of the Chest·G E Burch, N P DePasquale
Sep 1, 1965·Journal of Applied Physiology·E W MerrillE W Salzman
Mar 11, 1984·The American Journal of Physiology·T AversanoJ M Canty
Feb 1, 1980·The American Journal of Cardiology·K L Gould

❮ Previous
Next ❯

Citations

Sep 21, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Cihan DündarCevat Kırma
Jan 1, 1996·Archives of Gerontology and Geriatrics·M PonzettoM Molaschi
Jun 1, 2005·Anesthesiology Clinics of North America·Mercy Kuriyan, Jeffrey L Carson
Apr 13, 2005·International Journal of Cardiology·Erik LipsicFelix Zijlstra
Jul 1, 1995·The American Journal of Cardiology·G N LevineG J Balady
Oct 15, 2003·Blood Reviews·S A McLellanT S Walsh
Oct 30, 2001·The New England Journal of Medicine·W C WuH M Krumholz
Jan 3, 2012·QJM : Monthly Journal of the Association of Physicians·Donald S C AngA D Struthers
Mar 14, 2001·Critical Care Medicine·P C HébertUNKNOWN Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group
Sep 26, 2003·Current Opinion in Critical Care·Ronald S Freudenberger, Jeffrey L Carson
Jan 10, 2009·Artificial Organs·Robert D SlightPankaj S Mankad
Apr 29, 1998·Pacing and Clinical Electrophysiology : PACE·Y YamanouchiF M Fouad-Tarazi
Feb 27, 2008·Journal of Biomechanical Engineering·Ohwon KwonRupak K Banerjee
Oct 1, 1990·British Heart Journal·E ErnstH F Paulsen
Sep 21, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ajvor LukinLivia Puljak
Feb 28, 2007·Vascular Health and Risk Management·Leila Fernandes AraujoCarlos V Serrano
Jun 19, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S A WintherC Andersson
Feb 19, 2008·Coronary Artery Disease·Anderson D da SilveiraCarisi A Polanczyk
May 27, 2003·British Journal of Anaesthesia·T S Walsh, D B L McClelland
Mar 24, 2012·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Ana Teresa TimóteoRui Cruz Ferreira
Dec 14, 2011·The American Journal of Cardiology·John O YoungeRon T van Domburg
Nov 26, 2010·International Journal of Cardiology·Manuela B SangoiRafael N Moresco
Sep 1, 2008·Revista española de cardiología·Juan José González-FerrerCarlos Macaya
Aug 2, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Zehra JafferyChristopher J White
Feb 7, 2009·The American Journal of Cardiology·Nicolas MeneveauUNKNOWN Reseau de Cardiologie de Franche Comte
Jul 26, 2011·The American Journal of Cardiology·Adam C SalisburyFrederick A Masoudi
May 12, 2004·Critical Care Clinics·Paul C HébertLing Qun Hu
Aug 13, 2011·American Heart Journal·Adam C SalisburyMikhail Kosiborod
Nov 10, 2010·The American Journal of Cardiology·Melissa RousseauUNKNOWN Integrilin and Enoxaparin Randomized Assessment of Acute Coronary Syndrome Treatment (INTERACT) Trial Investigators
May 31, 2017·European Heart Journal. Acute Cardiovascular Care·Lea Ohana-Sarna-Cahan, Shaul Atar
Mar 21, 2012·The Journal of International Medical Research·Y LiuJ D Li

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