Effect of a selective 5-HT3 receptor agonist on gastric motility in fasted and fed dogs

European Journal of Pharmacology
Y NagakuraK Miyata

Abstract

The effect of m-chlorophenylbiguanide, a selective 5-HT3 receptor agonist, on gastric antral motility was investigated in conscious dogs with a force transducer implanted chronically. m-Chlorophenylbiguanide (0.1-1 mg/kg i.v.) dose dependently enhanced antral motility in the fasted state, and the amplitude of m-chlorophenylbiguanide (1 mg/kg i.v.)-induced antral contractions reached the level of natural phase III contractions. In contrast, m-chlorophenylbiguanide reduced the amplitude of antral contractions in the fed state. A selective 5-HT3 receptor antagonist, ramosetron (0.0003-0.03 mg/kg i.v.), inhibited both effects of m-chlorophenylbiguanide. m-Chlorophenylbiguanide (1 mg/kg i.v.)-induced contractions were inhibited by atropine (0.03 or 0.1 mg/kg i.v.). These results indicate that pharmacological activation of 5-HT3 receptors has opposite effects on canine gastric antral motility in the fasted and in the fed state, being stimulatory and inhibitory, respectively. The stimulatory effect seems to be mediated mainly via the release of acetylcholine.

References

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Citations

Jul 11, 2002·Life Sciences·Yukinori NagakuraTokio Yamaguchi
Dec 6, 2002·British Journal of Pharmacology·P JanssenR A Lefebvre
Oct 24, 2013·World Journal of Gastroenterology : WJG·Hiroki MoritaHiroyuki Kuwano
Aug 19, 2009·Annals of the New York Academy of Sciences·Vasiliy ZolotarevKunio Torii
May 18, 2021·Journal of Equine Veterinary Science·Alshimaa M M Farag, Hussam M M Ibrahim

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