Abstract
Selective estrogen receptor modulators (SERMs) are drugs used to treat osteoporosis. Selective estrogen receptor modulators improve bone mineral density and bone mechanical strength. However, there is a lack of data on the effect of SERMs on osteoporotic spinal fusion. This study aimed to investigate whether treatment with a SERM enhances spinal fusion in an ovariectomized (OVX) rat model. An in vivo animal study was carried out. Female Sprague Dawley rats (n=90) were OVX or sham-operated, and randomized into three groups: control (sham-operated+fusion procedure+saline administration), OVX (OVX+fusion procedure+saline administration), and SERM (OVX+fusion procedure+administration of SERM). Eight weeks after OVX, a bilateral lumbar spinal fusion procedure was performed using autologous iliac bone. In each group, gene expression was evaluated at 2, 4, and 8 weeks after the fusion procedure, histologic analysis was performed at 4 and 8 weeks after the procedure, and bone parameters were measured by micro-computed tomography at 2 days, 4 weeks, and 8 weeks after the procedure. Bone mineral density and trabecular quality of the vertebral body were significantly higher in the SERM group compared with the OVX group 16 weeks after OVX....Continue Reading
References
Dec 1, 1991·Bone and Mineral·D N Kalu
Jun 1, 1988·Spine·L L Wiltse, C W Spencer
Feb 15, 1995·Spine·S D BodenW C Hutton
Oct 1, 1995·Bone·S C MillerW S Jee
Oct 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D E HughesB F Boyce
Feb 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittB F Boyce
Aug 17, 1999·The Journal of Clinical Investigation·R L JilkaS C Manolagas
Apr 27, 2000·Endocrine Reviews·S C Manolagas
Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Dec 10, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yongping CaoHiromichi Norimatsu
Feb 14, 2003·The New England Journal of Medicine·B Lawrence Riggs, Lynn C Hartmann
Jan 30, 2004·The Spine Journal : Official Journal of the North American Spine Society·Ronald A LehmanK Daniel Riew
Mar 17, 2005·Endocrine Reviews·Anthony B HodsmanChui Kin Yuen
Nov 15, 2005·Spine·Russel C HuangJoseph M Lane
Aug 29, 2006·The Spine Journal : Official Journal of the North American Spine Society·David H Kim, Alexander R Vaccaro
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Mar 28, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D K ChinY E Cho
Oct 7, 2008·Bone·Masahiko TakahataAkio Minami
Dec 3, 2008·Langenbeck's Archives of Surgery·E K StuermerK M Stuermer
Oct 3, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nefise Ahmet-CamciogluMustafa Kucuk
Mar 25, 2010·Journal of Bone and Mineral Metabolism·Junichi TakadaToshihiko Yamashita
Apr 1, 2011·Lancet·Tilman D RachnerLorenz C Hofbauer
Jul 26, 2011·Bone·T HistingM D Menger
Sep 3, 2011·Journal of Korean Neurosurgical Society·Sung Bae Park, Chun Kee Chung
Nov 9, 2011·Journal of Midwifery & Women's Health·Kerri Durnell SchuilingRachel Nye
Mar 1, 2012·Bone·Kyae Hyung KimSang Min Park
Mar 9, 2012·Journal of Cancer Research and Clinical Oncology·Zhenzhen TuYueqing Gu
Apr 3, 2013·Journal of Bone and Mineral Metabolism·Alexander S SpiroFrank Timo Beil
Feb 4, 2014·The Spine Journal : Official Journal of the North American Spine Society·Sung Bae ParkChun Kee Chung
Citations
Nov 4, 2016·Annals of Biomedical Engineering·Wataru IshidaTimothy F Witham
May 12, 2017·Journal of Korean Neurosurgical Society·Sung Bae ParkChun Kee Chung
Sep 17, 2020·Journal of Orthopaedic Surgery and Research·Christina HolmesTimothy F Witham
Mar 16, 2018·Archives of Osteoporosis·Matthew T MorrisWoojin Cho
Jan 4, 2020·The Spine Journal : Official Journal of the North American Spine Society·Seong SonXiang Yun