PMID: 9185668Jun 1, 1997Paper

Effect of a serotonin agonist (sumatriptan) on the peptidergic innervation of the rat cerebral dura mater and on the expression of c-fos in the caudal trigeminal nucleus in an experimental migraine model

Journal of Neuroscience Research
E Knyihár-CsillikL Vécsei

Abstract

The supratentorial cerebral dura of the albino rat is equipped with a rich sensory innervation including nociceptive axons and their terminals, which display intense calcitonin gene-related peptide (CGRP) immunoreactivity both in the connective tissue and around blood vessels. Stereotactic electrical stimulation of the trigeminal (Gasserian) ganglion, regarded as an experimental migraine model, induces marked increase and disintegration of club-like perivascular CGRP-immunopositive nerve endings in the dura. Intravenous administration of sumatriptan, prior to electrical stimulation, prevents disintegration of perivascular terminals and induces accumulation of CGRP in terminal and preterminal portions of peripheral sensory axons. Consequently, immunopositive terminals and varicosities increase in size; accumulation of axoplasmic organelles results in a "hollow" appearance of many varicosities. Since sumatriptan exerts its anti-migraine effect by virtue of its agonist action on 5-HT1D receptors, we suggest that sumatriptan prevents the release of CGRP from dural perivascular terminals by an action at 5-HT1D receptors. In the caudal trigeminal nucleus electrical stimulation of the trigeminal ganglion induces, in interneurons, incr...Continue Reading

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Citations

Sep 12, 2009·European Journal of Pharmacology·Eniko VamosLaszlo Vecsei
May 26, 2005·Brain Research. Brain Research Reviews·Lars Edvinsson, Rolf Uddman
Jan 5, 2002·Expert Opinion on Investigational Drugs·S A Doggrell
Dec 17, 2009·The Journal of Headache and Pain·Peer Carsten Tfelt-Hansen
May 29, 2004·Neuropharmacology·Geoffrey Andrew LambertAlessandro Stefano Zagami
Sep 4, 2013·Cephalalgia : an International Journal of Headache·Roshni RamachandranJes Olesen
Apr 26, 2002·Cephalalgia : an International Journal of Headache·R UddmanL Edvinsson
Sep 18, 2018·Expert Opinion on Drug Discovery·Heitor G Araújo-FilhoJullyana S S Quintans
Jan 4, 2006·CNS Drug Reviews·Geoffrey A Lambert
Jan 29, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zsuzsanna BohárLászló Vécsei
Jun 3, 2011·Headache·Saurabh GuptaB Lee Peterlin

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