Effect of a single overnight topical application of miconazole nitrate paste on acne papules

International Journal of Dermatology
Caroline FlagothierGérald E Piérard

Abstract

The classical management of acne calls for prolonged oral and/or topical treatments; however, some patients request a rapid effect to make the papules disappear within a few hours or days. To test the effect of a single overnight application of a paste containing 0.25% miconazole nitrate on acne papules, and comparison with the effect of the same but unmedicated paste. Narrow-band reflectance spectroscopy was used to assess the changes in E index (erythema) after overnight application of the pastes. In the first study, a total of 117 acne papules were assessed in 15 adolescents. Measurements of the E index were performed at 24-h intervals for 4 days on acne papules and the surrounding normal-looking skin. The last two assessments were performed the mornings preceding and following, respectively, a single application of the medicated paste. The second part of the study consisted of a double-blind, split-face study on 25 adolescents with acne. They applied each of the two formulations on a randomized part of the forehead. A total of 161 acne papules received the medicated paste and 160 received the same but unmedicated paste. Measurements were performed the mornings before and after the overnight treatment. In the first part of t...Continue Reading

References

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Apr 29, 1998·Journal of the European Academy of Dermatology and Venereology : JEADV·G E Piérard
Feb 28, 2002·Skin Pharmacology and Applied Skin Physiology·Claudine Piérard-FranchimontGérald E Piérard
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Citations

Dec 25, 2012·Archives of Pharmacal Research·Bram BaertBart De Spiegeleer
Jul 17, 2008·Expert Opinion on Pharmacotherapy·Pascale QuatresoozGérald E Piérard

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