Effect of a Sodium and Calcium DL-β -Hydroxybutyrate Salt in Healthy Adults

Journal of Nutrition and Metabolism
Tobias FischerThorsten Marquardt

Abstract

Ketone body therapy and supplementation are of high interest for several medical and nutritional fields. The intake of ketone bodies is often discussed in relation to rare metabolic diseases, such as multiple acyl-CoA dehydrogenase deficiency (MADD), that have no alternatives for treatment. Case reports showed positive results of therapy using ketone bodies. The number of ketone body salts offered on the wellness market is increasing steadily. More information on the kinetics of intake, safety, and tolerance of these products is needed. In a one-dose kinetic study, six healthy subjects received an intervention (0.5 g/kg bw) using a commercially available ketone body supplement. The supplement contained a mixture of sodium and calcium D-/L-β-hydroxybutyrate (βHB) as well as food additives. The blood samples drawn in the study were tested for concentrations of D-βHB, glucose, and electrolytes, and blood gas analyses were done. Data on sensory evaluation and observed side effects of the supplement were collected. The product also went through chemical food analysis. The supplement led to a significant increase of D-βHB concentration in blood 2.5 and 3 h after oral intake (p=0.033; p=0.043). The first significant effect was measure...Continue Reading

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Citations

Nov 16, 2019·Medicine and Science in Sports and Exercise·Mark EvansBrendan Egan
Jul 18, 2019·Molecular Genetics and Metabolism Reports·Tobias FischerThorsten Marquardt
Mar 13, 2020·The Journal of Nutritional Biochemistry·Rachel M GolonkaMatam Vijay-Kumar
Mar 2, 2021·The Journal of Physiology·Qutuba G Karwi, Gary D Lopaschuk
Mar 12, 2021·Cardiovascular Research·Shingo TakaharaJason R B Dyck
Jun 3, 2021·International Journal of Molecular Sciences·Michael Scott Williams, Edward Turos
Aug 21, 2021·Applied Microbiology and Biotechnology·Aliya YaoGuo-Qiang Chen
May 16, 2019·Developmental Neuroscience·Thomas R WoodSandra E Juul

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Methods Mentioned

BETA
enzymatic assay

Software Mentioned

Excel
SPSS Statistics

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