Effect of a stannous fluoride toothpaste on dentinal hypersensitivity: In vitro and clinical evaluation

The Journal of the American Dental Association
Deon HinesMalcolm Williams

Abstract

The authors conducted an in vitro and a clinical study to assess the effect of a toothpaste containing stannous fluoride to occlude dentin tubules and reduce dentinal hypersensitivity. For the in vitro study, the authors treated the surface of human dentin specimens with test or control toothpaste slurries and then evaluated them by using various spectroscopic techniques. For the clinical study, male and female participants who met the inclusion criteria brushed their teeth twice daily for 1 minute with test or control toothpaste. The authors assessed dentinal hypersensitivity by using tactile and air blast stimuli at baseline and after 4 and 8 weeks. All statistical tests of hypotheses were 2 sided, with a significance level of α set at .05. Results from in vitro studies showed that the test toothpaste effectively occluded the dentinal tubules with a deposit consisting of tin, zinc, phosphate, and silicon. The test and control toothpastes occluded the tubules 82% and 35%, respectively. Clinically, at the 4- and 8-week examinations, the test toothpaste provided statistically significant (P < .001) improvements in tactile dentinal hypersensitivity scores of 27.8% and 42.0% and in air blast hypersensitivity scores of 21.4% and 32...Continue Reading

Citations

Jun 25, 2019·Journal of Applied Biomaterials & Functional Materials·Stanley Chibuzor OnwubuPhumlane Selby Mdluli
Jan 15, 2021·International Journal of Nanomedicine·Bolin LiHaiyan Lu
Oct 17, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Behrad MahmoodiRichard B Cook
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meenakshi RajendiranLin Chen

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