Effect of A Sun Protection Intervention on the Immune Response to Measles Booster Vaccination in Infants in Rural South Africa

Photochemistry and Photobiology
Caradee Y WrightPatricia N Albers

Abstract

The incidence of many serious childhood infections can be reduced by vaccination. High sun exposure at the time of vaccination has been associated with a reduced antigen-specific immune response. We hypothesized that providing sun protection advice and equipment to mothers of children who were waiting to be vaccinated would result in a more robust immunization response. We conducted a pilot study in 2015/2016 (data analyzed in 2017-2018) among 98 Black African children (~18 months of age) receiving the booster measles vaccination at two clinics in South Africa. Clinics were randomized to receive (or not) sun protection advice and equipment. We recorded demographic information on children and mothers and data on the child's usual sun exposure. At approximately 4 weeks' postmeasles vaccination, we measured measles immunoglobulin G levels in children. All children with blood results (n = 87, 89%) across both groups had antibody titers higher than 200 mIU mL-1 which was considered the protective antibody concentration. There was no statistically significant difference in titers between groups: geometric difference in mean titers 1.13 mIU mL-1 (95% CI 0.85, 1.51; P = 0.39) and 1.38 mIU mL-1 (95% CI 0.90, 2.11, P = 0.14) for unadjust...Continue Reading

References

Nov 5, 1999·Pediatrics·M PapaniaL Markowitz
May 3, 2000·Australian and New Zealand Journal of Public Health·W R StantonM Eyeson-Annan
Aug 31, 2001·The Journal of Infectious Diseases·H GansA M Arvin
Sep 17, 2002·Methods : a Companion to Methods in Enzymology·Annemarie SleijffersHenk Van Loveren
May 20, 2008·Vaccine·Paul Henri Lambert, Philippe E Laurent
Jul 2, 2008·BMC Public Health·Patricia M Lund, Julie S Taylor
Nov 6, 2009·Journal of Tropical Pediatrics·Nehama LinderItzhak Levy
Feb 23, 2010·American Journal of Preventive Medicine·Latrice C PichonGregory J Norman
Mar 25, 2010·BMJ : British Medical Journal·Kenneth F SchulzUNKNOWN CONSORT Group
May 21, 2010·BMJ : British Medical Journal·E LeuridanP Van Damme
Dec 2, 2010·Advances in Experimental Medicine and Biology·David E Bloom
Dec 3, 2010·Early Human Development·J P van den BergR M van Elburg
Jul 14, 2011·Photochemistry and Photobiology·Mary Norval, Gary M Halliday
Aug 20, 2011·Nature Reviews. Immunology·Prue H HartJohn J Finlay-Jones
Dec 27, 2012·Journal of the American Academy of Dermatology·Annika SmithRobert Maclennan
May 16, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter AabyChristine S Benn
Jun 2, 2016·Human Vaccines & Immunotherapeutics·Ezzeldin SalehEmmanuel B Walter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.