Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis

Drug Design, Development and Therapy
Nemat Z YassinSherine Helmy

Abstract

We aimed to investigate the effect of topical application of a Copper indomethacin (Cu-Indo) gel preparation on monosodium iodoacetate (MIA) induced arthritis of the knee joint of rats and to test our hypothesis that copper complex of indomethacin could be a more potent anti-inflammatory agent than its parent compound. After induction of osteoarthritis by the intracapsular injection of 50 μL with 40 mg/mL MIA, we compared the anti-inflammatory efficacy and safety of a topical application of 1% indomethacin gel in a dose of 1 g/kg of the gel (equivalent to 10 mg/kg of the active substance) daily for 3 weeks versus three decremental dose levels of Cu-Indo gel: an equivalent dose, half the dose, and 25% of the dose of indomethacin. Anti-inflammatory efficacy was assessed in all treated groups by measurement of serum inflammatory cytokines: interleukin 6, interleukin 8, and tumor necrosis factor alpha; and by the weekly assessment of knee joint swelling. Joint mobility and motor coordination were also assessed once weekly by the accelerating rotarod apparatus; histopathological examination of affected joints was also performed. Safety of topical application of Cu-Indo (0.25, 0.5, and 1 g/kg) for up to 3 months to rats' skin was det...Continue Reading

Citations

Oct 26, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Graham E JacksonRaffaele P Bonomo
Jun 4, 2020·International Journal of Molecular Sciences·Olga KrasnovskayaAlexander Majouga
Jan 3, 2019·Inflammopharmacology·Kizhakkeppurath Kumaran AjeeshkumarGopinathan Pillai Sreekanth

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