Effect of a training and educational intervention for physicians and caregivers on antibiotic prescribing for upper respiratory tract infections in children at primary care facilities in rural China: a cluster-randomised controlled trial

The Lancet Global Health
Xiaolin WeiMei Lin

Abstract

Inappropriate antibiotic prescribing contributes to the generation of drug resistance worldwide, and is particularly common in China. We assessed the effectiveness of an antimicrobial stewardship programme aiming to reduce inappropriate antibiotic prescribing in paediatric outpatients by targeting providers and caregivers in primary care hospitals in rural China. We did a pragmatic, cluster-randomised controlled trial with a 6-month intervention period. Clusters were primary care township hospitals in two counties of Guangxi province in China, which were randomly allocated to the intervention group or the control group (in a 1:1 ratio in Rong county and in a 5:6 ratio in Liujiang county). Randomisation was stratified by county. Eligible participants were children aged 2-14 years who attended a township hospital as an outpatient and were given a prescription following a primary diagnosis of an upper respiratory tract infection. The intervention included clinician guidelines and training on appropriate prescribing, monthly prescribing peer-review meetings, and brief caregiver education. In hospitals allocated to the control group, usual care was provided, with antibiotics prescribed at the individual clinician's discretion. Patie...Continue Reading

Citations

Nov 20, 2019·Journal for Specialists in Pediatric Nursing : JSPN·Songul Cinaroglu
Jan 21, 2020·Antimicrobial Resistance and Infection Control·Jie ChenTherese Hesketh
Jan 9, 2020·Antimicrobial Resistance and Infection Control·D DonàM Sharland
Jul 12, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Jia YinCecilia Stålsby Lundborg
Jul 27, 2018·Health Research Policy and Systems·John WalleyXiaolin Wei
Jan 29, 2021·Expert Review of Anti-infective Therapy·Jianxiong WuXiaoxv Yin
Jul 11, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hui LiXiaoxv Yin
Jan 8, 2021·Antimicrobial Resistance and Infection Control·Xuemei ZhenHengjin Dong
May 10, 2020·Antimicrobial Resistance and Infection Control·D DonàM Sharland
Apr 26, 2021·The Lancet Infectious Diseases·John D WalleyXiaolin Wei
May 12, 2021·NPJ Primary Care Respiratory Medicine·Mengyuan FuDennis Ross-Degnan
Jun 3, 2021·BMC Pediatrics·Shasha GuoXuemei Zhen
Jul 15, 2021·Antimicrobial Resistance and Infection Control·Jun Wern YauChris Rissel

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