Effect of ABCA1 mutations on risk for myocardial infarction.

Current Atherosclerosis Reports
Iulia IatanJ Genest

Abstract

The adenosine triphosphate-binding cassette A1 (ABCA1) gene codes for a cellular phospholipid and cholesterol transporter that mediates the initial and essential step in high-density lipoprotein (HDL) biogenesis: the formation of nascent HDL particles. Mutations at the ABCA1 gene locus cause severe familial HDL deficiency and, in the homozygous form, cause Tangier disease. Several studies have investigated the influence of ABCA1 variation on lipid metabolism and coronary heart disease, but they have resulted in controversial and inconsistent results. Genetic variability at the ABCA1 gene has also been associated with increased risk of myocardial infarction. In one study, this association was independent of HDL cholesterol levels, raising the possibility that the measurement of HDL cholesterol levels may not provide adequate information on the functional roles of HDL particles. Nevertheless, genomic screening for complex diseases, such as coronary heart disease, and HDL deficiency in particular, may not add additional information to that gained from conventional global cardiovascular risk stratification.

References

Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H J ParraG Luc
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·A T RemaleyH B Brewer
Mar 22, 2000·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·G SchmitzW Drobnik
Nov 5, 2002·Annual Review of Medicine·Gerd Assmann, Jerzy-Roch Nofer
Apr 18, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·David Evans, F Ulrich Beil
May 24, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Roshni R SingarajaMichael R Hayden
Feb 14, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·David-Alexandre TregouetFrancois Cambien
May 12, 2004·Atherosclerosis·Stefano BertoliniSebastiano Calandra
Jun 26, 2004·Current Opinion in Cardiology·Michael Miller, Min Zhan
Aug 7, 2004·Science·Jonathan C CohenHelen H Hobbs
Nov 3, 2004·The Journal of Clinical Investigation·Ruth Frikke-SchmidtAnne Tybjaerg-Hansen
Nov 6, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Theodosios KyriakouShu Ye
Apr 21, 2005·The Journal of Clinical Investigation·Jenelle M TimminsJohn S Parks
May 18, 2005·Journal of Lipid Research·Larbi KrimbouJacques Genest
Jun 28, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·P J Barter
Oct 18, 2005·Journal of the American College of Cardiology·Ruth Frikke-SchmidtAnne Tybjaerg-Hansen
Nov 30, 2005·International Journal of Cardiology·María MartínCésar Morís
Mar 18, 2006·The Journal of Clinical Investigation·Liam R BrunhamMichael R Hayden
Jun 8, 2007·BMC Medical Genetics·Alireza PasdarMary-Joan MacLeod
Oct 24, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Ruth Frikke-SchmidtAnne Tybjaerg-Hansen
Mar 21, 2008·The New England Journal of Medicine·Sekar KathiresanMarju Orho-Melander
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos

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Citations

Apr 25, 2012·Current Atherosclerosis Reports·Iulia IatanJacques Genest
Apr 15, 2011·Cholesterol·Eric CoomesAllison B Reiss
Feb 27, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Javier Delgado-ListaJose Lopez-Miranda
Jun 1, 2010·Clinical Lipidology·Sadik H KassimDaniel J Rader
Feb 28, 2014·Internal and Emergency Medicine·Tiziano LucchiCarlo Vergani
Mar 1, 2011·Progress in Lipid Research·Iryna Voloshyna, Allison B Reiss
Dec 3, 2010·Journal of Clinical Lipidology·Peter P Toth, Michael H Davidson
Dec 18, 2015·Trends in Endocrinology and Metabolism : TEM·Henry J Pownall, Antonio M Gotto
Jul 11, 2020·Cellular & Molecular Biology Letters·Ambroise WuTomasz Trombik
Jun 18, 2009·Molecular Cancer Therapeutics·Steven E TrasinoThomas T Y Wang
May 1, 2021·International Journal of Molecular Sciences·Shiraz DibFabien Gosselet

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