PMID: 11903414Mar 21, 2002Paper

Effect of acarbose on weight maintenance after dietary weight loss in obese subjects

Diabetes, Obesity & Metabolism
H HaunerH Toplak

Abstract

Acarbose is a well established antidiabetic drug and is known to exert a modest weight-lowering effect. The aim of this study was to assess the potential of acarbose to improve weight maintenance after a substantial weight loss by dietary measures in obese subjects. Randomised, double-blind, placebo-controlled trial of the effect of acarbose on weight change over a 6-month follow-up period. One hundred and ten obese subjects with a BMI > or = 32 and < or = 38 kg/m2 were included in the study and underwent a 10-16-week very-low-calorie diet programme to initiate weight loss. Then, subjects were randomised to receive either acarbose or placebo for 26 +/- 2 weeks. The primary variable was body weight. The primary efficacy analysis was performed in the per-protocol population (n = 75). After an initial mean weight loss of 10.0 +/- 3.4 kg, 54 subjects received acarbose at increasing dosage and 56 subjects received placebo treatment. After 14 weeks of follow-up, there was no change in body weight in the two groups. After 26 weeks, completed by 37 subjects in the acarbose group and by 38 subjects in the placebo group, a small weight regain of 0.6 kg was documented in the latter, whereas no weight increase was observed under acarbose t...Continue Reading

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Citations

Sep 3, 2013·Diabetes Research and Clinical Practice·Jun-Sing WangUNKNOWN acarbose/metformin fixed-dose combination study investigators
Dec 31, 2008·The Journal of Cardiovascular Nursing·Melanie Warziski TurkLora E Burke
Jan 12, 2012·AAPS PharmSciTech·Ruchita V Kumar, Vivek Ranjan Sinha
Jun 9, 2005·Journal of the American Dietetic Association·Susan B Moyers
Mar 1, 2012·Orvosi hetilap·Gábor SimonyiJ Róbert Bedros
Mar 26, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anders Lehmann, Pamela J Hornby
Aug 25, 2019·Nutrients·Marlene A van Baak, Edwin C M Mariman

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