Effect of accelerated electron beam on mechanical properties of human cortical bone: influence of different processing methods.

Cell and Tissue Banking
Artur KaminskiIzabela Uhrynowska-Tyszkiewicz

Abstract

Accelerated electron beam (EB) irradiation has been a sufficient method used for sterilisation of human tissue grafts for many years in a number of tissue banks. Accelerated EB, in contrast to more often used gamma photons, is a form of ionizing radiation that is characterized by lower penetration, however it is more effective in producing ionisation and to reach the same level of sterility, the exposition time of irradiated product is shorter. There are several factors, including dose and temperature of irradiation, processing conditions, as well as source of irradiation that may influence mechanical properties of a bone graft. The purpose of this study was to evaluate the effect e-beam irradiation with doses of 25 or 35 kGy, performed on dry ice or at ambient temperature, on mechanical properties of non-defatted or defatted compact bone grafts. Left and right femurs from six male cadaveric donors, aged from 46 to 54 years, were transversely cut into slices of 10 mm height, parallel to the longitudinal axis of the bone. Compact bone rings were assigned to the eight experimental groups according to the different processing method (defatted or non-defatted), as well as e-beam irradiation dose (25 or 35 kGy) and temperature condi...Continue Reading

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Citations

Jan 1, 2014·Journal of Clinical Medicine·Patrick BabczykEdda Tobiasch
Mar 25, 2014·Expert Review of Medical Devices·Luis M DelgadoDimitrios I Zeugolis
Sep 4, 2015·Biomaterials Research·Soung Min KimSuk Keun Lee
Sep 26, 2016·Cell and Tissue Banking·J MohrUNKNOWN Bioburden Steering Committee and Musculoskeletal Tissue Working group
Aug 22, 2014·The Journal of Bone and Joint Surgery. American Volume·Egleide Y Elenes, Shawn A Hunter
Jan 25, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jeremy V SuhardiEbru Oral
Dec 10, 2020·Bioactive Materials·Zhengwei LiXufeng Niu
Mar 6, 2021·The Ocular Surface·Sina SharifiJames Chodosh
Mar 13, 2021·Xenotransplantation·Héctor Capella-Monsonís, Dimitrios I Zeugolis

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