Effect of acetazolamide and subsequent ventriculo-peritoneal shunting on clinical signs and ventricular volumes in dogs with internal hydrocephalus

Acta Veterinaria Scandinavica
Malgorzata KoleckaMartin J Schmidt

Abstract

Acetazolamide is recommended for the reduction of cerebrospinal fluid production in canine internal hydrocephalus. The efficacy of the drug in terms of alleviation of the clinical symptoms and the restoration of normal ventricular volume has not been documented. We hypothesize that acetazolamide inadequately improve clinical signs and has no effect on the ventricular volume. Six dogs with internal hydrocephalus underwent neurological examination and were examined by magnetic resonance imaging, on the day of the diagnosis, after treatment with acetazolamide directly before surgery, and 6 weeks after implantation of a vetriculo-peritoneal shunt due to lack of improvement after medical therapy with 10 mg/kg acetazolamide three times daily (TID). The ventricular volume in relation to the total brain volume was determined on each occasion. The changes in relative ventricular volume and of the neurological status were assessed and compared. McNemar's test revealed no significant differences in clinical symptoms before and after medical treatment (P > 0.05). However, clinical symptoms changed significantly after surgical treatment (P = 0.001). The ventricle-brain ratio was not significantly changed after therapy with acetazolamide (P ...Continue Reading

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Citations

Feb 6, 2016·Fluids and Barriers of the CNS·Marc R Del Bigio, Domenico L Di Curzio
Nov 27, 2019·Fluids and Barriers of the CNS·Sajedeh EftekhariRigmor Hoejland Jensen
Jun 22, 2020·Acta Veterinaria Scandinavica·Diego Noé Rodríguez-SánchezRogério Martins Amorim
Mar 20, 2019·Journal of the American Veterinary Medical Association·Sabrina GillespieSteven De Decker
Jun 22, 2021·CNS Neuroscience & Therapeutics·Chuansen WangGelei Xiao
Jul 10, 2021·Journal of the Neurological Sciences·Timothy WongIra Goldstein

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