Effect of acetochlor on transcription of genes associated with oxidative stress, apoptosis, immunotoxicity and endocrine disruption in the early life stage of zebrafish

Environmental Toxicology and Pharmacology
Jinhua JiangXueping Zhao

Abstract

The study presented here aimed to characterize the effects of acetochlor on expression of genes related to endocrine disruption, oxidative stress, apoptosis and immune system in zebrafish during its embryo development. Different trends in gene expression were observed after exposure to 50, 100, 200μg/L acetochlor for 96h. Results demonstrated that the transcription patterns of many key genes involved in the hypothalamic-pituitary-gonadal/thyroid (HPG/HPT) axis (e.g., VTG1, ERβ1, CYP19a and TRα), cell apoptosis pathway (e.g., Bcl2, Bax, P53 and Cas8), as well as innate immunity (e.g., CXCL-C1C, IL-1β and TNFα) were affected in newly hatched zebrafish after exposure to acetochlor. In addition, the up-regulation of CAT, GPX, GPX1a, Cu/Zn-SOD and Ogg1 suggested acetochlor might trigger oxidative stress in zebrafish. These finding indicated that acetochlor could simultaneously induce multiple responses during zebrafish embryonic development, and bidirectional interactions among oxidative stress, apoptosis pathway, immune and endocrine systems might be present.

References

Oct 1, 1995·Environmental Health Perspectives·J P Sumpter, S Jobling
Oct 1, 1995·Environmental Health Perspectives·S A HeppellC V Sullivan
Aug 15, 1997·The Biochemical Journal·G M Cohen
May 26, 1999·Archives of Environmental Contamination and Toxicology·A O CheekJ A McLachlan
Jan 7, 2000·Journal of Cellular Physiology·M S Sheikh, A J Fornace
Feb 15, 2001·Journal of Molecular Endocrinology·O MarchandV Laudet
Aug 22, 2001·Journal of Agricultural and Food Chemistry·L N Konda, Z Pásztor
Jan 31, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Aurea OrozcoCarlos Valverde-R
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martine BehraUwe Strähle
Oct 12, 2004·General and Comparative Endocrinology·Helen M CraneJ Anne Brown
May 3, 2005·The Science of the Total Environment·Lesley J Mills, Clinton Chichester
Jan 13, 2006·Ecotoxicology and Environmental Safety·Athanasios ValavanidisMichael Scoullos
Jan 31, 2006·International Journal of Hematology·Takanori SoMichael Croft
Nov 9, 2007·The Science of the Total Environment·Michelle L HladikA Lynn Roberts
Apr 11, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Nikolaos SofikitisNikolaos Pardalidis
May 13, 2008·Drug Discovery Today·Patricia McGrath, Chun-Qi Li
May 17, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Doug CrumpSean W Kennedy
Jun 10, 2008·Neurotoxicology·Randall T PetersonToshio Narahashi
Jun 26, 2008·Environmental Science and Pollution Research International·Stefan ScholzDoris Voelker
Sep 20, 2008·Environmental Science & Technology·Xiaowei ZhangJohn P Giesy
Mar 12, 2009·Current Drug Metabolism·Chiranjib ChakrabortyGovindasamy Agoramoorthy
May 2, 2009·Reproductive Toxicology·Lixin YangUwe Strähle
Nov 17, 2009·Biochemical Pharmacology·Mary-Line JuganJean-Paul Blondeau
Mar 2, 2011·The Journal of Experimental Medicine·Edwina Naik, Vishva M Dixit
Apr 24, 2012·Ecotoxicology and Environmental Safety·He TangtianRudolf S S Wu
Feb 27, 2014·Journal of Biomedical Semantics·Ceri E Van SlykeMelissa A Haendel
Oct 8, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Tamanna ZerinYong-Sik Kim
Nov 25, 2014·Bulletin of Environmental Contamination and Toxicology·Daniela S Garanzini, Mirta L Menone

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Citations

Dec 6, 2016·Chemosphere·Xia WangZhengwei Fu
Apr 21, 2017·Critical Reviews in Toxicology·Kristina RehbergerLisa Baumann
Sep 21, 2017·International Journal of Molecular Sciences·Chien-Hsun Huang, Wen-Hsiung Chan
Jan 15, 2020·Environmental Science and Pollution Research International·Yiming ChangHongyun Jiang
Feb 18, 2020·Environmental Science and Pollution Research International·Íris Flávia Sousa GonçalvesDavi Felipe Farias
Jan 3, 2021·Archives of Environmental Contamination and Toxicology·P A Opute, I P Oboh
Apr 10, 2018·The Science of the Total Environment·Le QianChengju Wang
Aug 21, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Wen XueWenzhi Wei
Nov 1, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Hokyun KimKyunghwa Park

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