PMID: 7526335Jul 1, 1994Paper

Effect of acetyl choline on ion transport in sheep tracheal epithelium

Pflügers Archiv : European journal of physiology
M Acevedo

Abstract

The action of acetylcholine (ACh) on sheep tracheal epithelium has been investigated. ACh increases transiently the short-circuit current (ISC). The same response is obtained in tissues in which the apical membrane has been permeabilized with amphotericin B in the presence of a potassium gradient. Microelectrode studies show that the majority of tracheal epithelial cells depolarize as the apical fractional resistance decreases on application of ACh. These results, together with the finding that bumetanide decreases the initial ACh-induced ISC increase, are consistent with an initial activation by ACh of apical Cl- channels and basolateral K+ channels. Following the initial increase, ISC declines to values lower than in control conditions both in untreated and in amphotericin-permeabilized tissues, suggesting that the basolateral K+ conductance falls during this phase. The late decrease in ISC induced by ACh is significantly reduced in tissues pretreated with amiloride, suggesting that the apical Na+ channels are also involved in this response. ACh abolishes the net Na+ absorption by decreasing the mucosal to serosal Na+ flux. This effect is possibly a result of a down-regulation of apical Na+ channels and basolateral K+ channels.

References

Mar 1, 1990·The Journal of Physiology·M AcevedoM R Ward
Jun 1, 1990·The American Journal of Physiology·B Winding, N Bindslev
Jan 1, 1991·Life Sciences·J M FarleyT M Dwyer
Apr 1, 1990·The American Journal of Physiology·A G ButtR A Frizzell
Jan 1, 1989·Methods in Enzymology·S A Lewis, N K Wills
Nov 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C U CottonJ T Gatzy

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Citations

Jul 22, 1998·European Journal of Pharmacology·T ReinheimerI Wessler
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kamel MaoucheJean-Marie Tournier
Nov 17, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chelsea J Martens, Stephen T Ballard
Apr 9, 2005·American Journal of Respiratory Cell and Molecular Biology·Katrin Susanne LipsHermann Koepsell
Apr 1, 1997·The Journal of Clinical Investigation·N IwaseK Shirato
Jul 29, 2009·Pulmonary Pharmacology & Therapeutics·E D BatemanI Wessler
Jan 5, 2011·British Journal of Pharmacology·Bart C Moulton, Allison D Fryer
Dec 2, 2011·Journal of Biomedicine & Biotechnology·Monika I HollenhorstMartin Fronius
Jan 1, 2013·Genes·Wymke OckengaRitva Tikkanen
Sep 21, 2000·Proceedings of the Society for Experimental Biology and Medicine·R CastroJ R Martinez
May 27, 2008·British Journal of Pharmacology·I Wessler, C J Kirkpatrick
Dec 22, 2007·Journal of Receptor and Signal Transduction Research·Peter KovacicChristine D Draskovich
Aug 20, 2011·American Journal of Respiratory Cell and Molecular Biology·Monika I HollenhorstMartin Fronius
Jan 15, 2002·American Journal of Physiology. Cell Physiology·Pejvak SassaniIra Kurtz
May 6, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jin Hyeok JeongJeffrey J Wine
Feb 6, 2016·Scientific Reports·Nam Soo JooJeffrey J Wine
Mar 24, 2020·International Immunopharmacology·Ignaz Wessler, Charles James Kirkpatrick
Jan 10, 2002·Pulmonary Pharmacology & Therapeutics·I K Wessler, C J Kirkpatrick

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