Effect of Acetyl-L-Carnitine on Antioxidant Status, Lipid Peroxidation, and Oxidative Damage of Arsenic in Rat

Biological Trace Element Research
Mohammad Reza SepandOmid Sabzevari

Abstract

Arsenic (As) is a widespread environmental contaminant present around the world in both organic and inorganic forms. Oxidative stress is postulated as the main mechanism for As-induced toxicity. This study was planned to examine the protective effect of acetyl-L-carnitine (ALC) on As-induced oxidative damage in male rats. Animals were randomly divided into four groups of control (saline), sodium arsenite (NaAsO2, 20 mg/kg), ALC (300 mg/kg), and NaAsO2 plus ALC. Animals were dosed orally for 28 successive days. Blood and tissue samples including kidney, brain, liver, heart, and lung were collected on the 28th day and evaluated for oxidative damage and histological changes. NaAsO2 exposure caused a significant lipid peroxidation as evidenced by elevation in thiobarbituric acid-reactive substances (TBARS). The activity of antioxidant enzymes such as glutathione-S-transferase (GST), catalase (CAT), superoxide dismutase (SOD), as well as sulfhydryl group content (SH group) was significantly suppressed in various organs following NaAsO2 treatment (P < 0.05). Furthermore, NaAsO2 administration increased serum values of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and bilirubin. Our fin...Continue Reading

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Citations

Dec 15, 2016·Journal of Exposure Science & Environmental Epidemiology·Yongyue WeiDavid C Christiani
Sep 8, 2017·Biological Trace Element Research·Ana Cláudia Ferreira SouzaMariana Machado-Neves
Dec 1, 2017·Biological Trace Element Research·Hedieh Keshavarz-BahaghighatOmid Sabzevari
Dec 10, 2019·Current Pharmaceutical Design·Giuseppe CarusoSara Merlo
May 6, 2017·Human & Experimental Toxicology·A A HemmatiH Yaghooti
Aug 25, 2019·Antioxidants·Bartosz KulczyńskiAnna Gramza-Michałowska
May 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandra DurazzoAntonello Santini
Feb 12, 2021·Chemical Research in Toxicology·Leah E LathamFang Liu
Mar 11, 2021·Environmental Research·Mohammad Reza SepandAmir Shadboorestan

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