Effect of acetylcholine and morphine on bronchial smooth muscle contraction and its modulation by steroid hormones

Clinical and Experimental Pharmacology & Physiology
B M NabishahB A Kadir

Abstract

1. The effects of corticosteroid pretreatment on acetylcholine (ACH)-induced contraction of bronchial smooth muscle (BSM) were studied. 2. ACH dose-response curves for dexamethasone (DM)- and corticosterone (B)-treated but not deoxycorticosterone (DOC)-treated BSM were significantly shifted to the right; this provides evidence that glucocorticoid treatment reduced the sensitivity of BSM to ACH. 3. Morphine enhanced BSM contraction in response to ACH by 20%. DM suppressed this enhancement. 4. These findings correlated well with the reduction of muscarinic receptor numbers in BSM by glucocorticoids in our previous study. In addition, glucocorticoids reduced the sensitivity of BSM to opioids.

References

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Citations

Dec 1, 1992·Clinical and Experimental Pharmacology & Physiology·B M NabishahB A Khalid
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S J Hirst, T H Lee
Dec 15, 2015·Pulmonary Pharmacology & Therapeutics·Mario CazzolaMaria Gabriella Matera
Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·M M McMahonB R Bistrian
Jul 1, 2020·Expert Review of Clinical Pharmacology·Luigino CalzettaMario Cazzola
Mar 26, 2019·American Journal of Respiratory Cell and Molecular Biology·Ajay P Nayak
Aug 20, 2019·Expert Review of Respiratory Medicine·Mario CazzolaPaola Rogliani
Feb 11, 2021·European Journal of Internal Medicine·Alberto PapiDave Singh
Jul 6, 2021·Expert Opinion on Pharmacotherapy·Josuel OraPaola Rogliani

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