PMID: 8961361Oct 1, 1996Paper

Effect of acetylsalicylic acid on radiation and cosmetic results after conservative surgery for early breast cancer: a randomized trial

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
I A OlivottoV E Basco

Abstract

Acetylsalicylic acid (ASA) can reduce the incidence of stroke and myocardial infarction by inhibiting platelet-fibrin thrombi in small blood vessels. To determine if ASA could reduce late effects of radiation therapy mediated by damage to small blood vessels, a prospective, placebo-controlled, double-blind trial was conducted in women with early breast cancer, receiving radiotherapy to the conserved breast. Cosmetic outcome and late radiotherapy effects were recorded prospectively for 186 women with T1 or T2, pathologically node-negative breast cancer treated with breast conservation and randomized to receive ASA (325 mg daily) or placebo for 1 year from the start of radiation therapy. Radiation was a tangent pair to the breast alone delivering a modal dose of 44 Gy in 16 daily fractions in 22-25 days. Median follow-up is 6.5 years. The use of ASA has not had any effect on the acute (erythema, edema or discomfort) or late (induration, telangiectasia) effects of radiotherapy (all P > 0.10), the patients' or physicians' assessment of the cosmetic outcome (all P > 0.25) or rates of breast recurrence (P > 0.25). ASA cannot be recommended to improve the outcome of radiotherapy complementing breast conserving surgery.

Citations

Jul 13, 2000·International Journal of Radiation Oncology, Biology, Physics·W ShelleyW Mackillop
Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·Y YamadaG Thomas
Apr 12, 2011·International Journal of Radiation Oncology, Biology, Physics·Christopher HerbertScott Tyldesley
Jul 3, 2007·International Journal of Radiation Oncology, Biology, Physics·Wilson MarhinScott Tyldesley
Mar 16, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·L LiviG P Biti
Mar 22, 2019·The Cancer Journal·Mohammad K KhanStephen J Kron

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