Effect of acid-base disturbances on aldosterone secretion in man

Journal of Endocrinological Investigation
T YamauchiN Matsui

Abstract

The present study was carried out to elucidate whether changes in blood pH induced by administration of alkalinizing and acidifying agents influence aldosterone secretion in man. Since aldosterone secretion is known to be regulated by various factors such as the renin-angiotensin system, adrenocorticotropic hormone (ACTH), and serum potassium concentration, these indices were simultaneously measured during manipulation. Oral administration of tris hydroxymethyl aminomethane (THAM) resulted in a moderate but not significant decrease in serum aldosterone together with an increase in blood pH, whereas plasma renin activity (PRA) remained unchanged and serum potassium was elevated. ACTH and cortisol decreased significantly. Following CaCO3 ingestion, blood pH, serum potassium concentration, and hormones did not change significantly compared with before ingestion. NH4Cl ingestion showed a significant fall of blood pH and serum cortisol, on the other hand, aldosterone increased significantly compared with CaCO3 ingestion. Following NaHCO3 ingestion, serum aldosterone decreased with an increase in blood pH compared with before ingestion, while serum cortisol and PRA did not change significantly. The overall results of experiments usin...Continue Reading

References

Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·G O PerezF H Katz
Jul 1, 1989·Acta Physiologica Scandinavica·O Augustinsson, A Forslid
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Sep 1, 1981·The American Journal of Medicine·H J Adrogué, N E Madias

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Citations

Nov 25, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B A R Lina, M H M Kuijpers
Sep 22, 2007·International Journal of Food Sciences and Nutrition·Stefanie SchoppenM Pilar Vaquero
Mar 28, 2012·The Journal of Medical Investigation : JMI·Kae YanagisawaShohei Onishi
Sep 29, 2020·American Journal of Physiology. Renal Physiology·Dominique M BoveeEwout J Hoorn

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