Effect of Acori graminei Rhizoma on contractile dysfunction of ischemic and reperfused rat heart

Biological & Pharmaceutical Bulletin
Moonkyu KangHyunsu Bae

Abstract

Acori graminei Rhizoma is one of the best-known traditional herbal medicines frequently used for the treatment of cardiovascular symptoms in Asian countries. The anti-ischemic effect of Acori graminei Rhizoma on ischemia-induced isolated rat heart was investigated through analysis of changes in perfusion pressure, aortic flow, coronary flow, and cardiac output. The subjects in this study were divided into two groups, an ischemia-induced group without any treatment (I), and an ischemia-induced group with Acori graminei Rhizoma treatment (I+AGR). There were no significant differences in perfusion pressure, aortic flow, coronary flow, or cardiac output between the two groups before ischemia was induced. The supply of oxygen and buffer was stopped for 10 min to induce ischemia in isolated rat hearts, and Acori graminei Rhizoma was administered while inducing ischemia. The data showed that Acori graminei Rhizoma treatment significantly prevented decreases in perfusion pressure, aortic flow, coronary flow, and cardiac output under an ischemic condition. In addition, hemodynamics (except heart rate) of the AGR-treated group was significantly recovered 60 min after reperfusion compared to the control group, (systolic aortic pressure: 8...Continue Reading

References

Jun 2, 1998·Free Radical Biology & Medicine·K I PriyadarsiniM N Rao
Feb 24, 2001·Antioxidants & Redox Signaling·M H Ben-MahdiC Pasquier
Oct 28, 2003·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Goro AsanoYuhichi Sugisaki
Mar 18, 2004·Current Medical Research and Opinion·Kohji Shirai
Mar 23, 2004·European Journal of Pharmacology·János MagyarPéter P Nánási
May 18, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michael GalagudzaJarle Vaage
Nov 20, 2004·Journal of Cardiovascular Pharmacology·Carlos Estevan Nolf DamianiDalton Valentim Vassallo
Apr 2, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hitoshi TominagaMasato Nomura

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Citations

Nov 30, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Qing LiuDaping Fan
Feb 13, 2015·Molecular Medicine Reports·Zhouqing HuangWeijian Huang
Nov 3, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ramalingam MaheshYong-Ki Park
Feb 5, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jong-Hyun NhoHyun-Woo Cho

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