Effect of activated charcoal in 70% sorbitol in healthy individuals

Journal of Toxicology. Clinical Toxicology
A MinochaD A Spyker

Abstract

Activated charcoal in 70% sorbitol enjoys wide use in the management of acute poisonings but the effects of the activated charcoal-sorbitol mixture in healthy individuals have not been characterized. We were concerned about the possibility of sorbitol causing changes in the routinely monitored serum chemistry and hematological parameters, either directly due to the absorbed polyol or due to the diarrhea induced by it, thus complicating the diagnosis and management in an overdose setting. We assessed the action of a single dose of 30g of activated charcoal in 150 ml of 70% sorbitol and its effects on serum osmolality, electrolytes, metabolic profile (SMAC), magnesium, hepatic enzymes, and complete blood count in healthy adult individuals. The only significant change in the laboratory parameters tested was the consistent rise in serum sodium and phosphorus concentrations four hours after drinking the charcoal-sorbitol mixture. However, a similarly consistent rise in the concentrations at the same hours on another day without ingestion of the charcoal-sorbitol mixture suggested the rise was due to circadian rhythm or other factors unrelated to the cathartic. The lack of effect on routinely monitored laboratory parameters, relative...Continue Reading

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Citations

Jan 11, 1991·Journal of Toxicology. Clinical Toxicology·A MinochaJ E Mayle
Sep 15, 2004·Journal of Toxicology. Clinical Toxicology
Oct 1, 1988·Annals of Emergency Medicine·E P Krenzelok, G P Lopez
Oct 1, 1990·Annals of Emergency Medicine·A M RowdenJ S Bertino
Aug 31, 2019·Journal of Veterinary Emergency and Critical Care·Katherine A MixErik Hofmeister
Jan 1, 1985·Journal of Toxicology. Clinical Toxicology·A MinochaD A Spyker
Jan 1, 1987·Journal of Toxicology. Clinical Toxicology·C D Curd-SneedJ J Stewart
Sep 1, 1990·DICP : the Annals of Pharmacotherapy·M W Veerman
Mar 1, 1988·The Journal of Emergency Medicine·D A Spyker, A Minocha
Aug 24, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Lotte C G HoegbergSophie Gosselin

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