PMID: 6404636Jan 1, 1983Paper

Effect of activated charcoal on absorption of tolbutamide and valproate in man

European Journal of Clinical Pharmacology
P J NeuvonenE L Hirvisalo

Abstract

The claim that activated charcoal should be ineffective or even contraindicated in intoxication due to tolbutamide is based only on limited in vitro studies. To test the claim, the effect of activated charcoal 50 g on the absorption of tolbutamide and, as a reference, of sodium valproate, was studied in 6 healthy volunteers. Each volunteer swallowed tolbutamide 500 mg and sodium valproate 300 mg with 50 ml water 1 h after a light breakfast, and within 5 min they took in randomized order either a suspension of activated charcoal or water. The absorption of tolbutamide, calculated as the peak concentration and the area under the serum drug concentration-time curve during 0-48 h, was reduced by 90% by charcoal (p less than 0.001). The absorption of valproate in these conditions was reduced on average by 65% (p less than 0.01). In each subject charcoal had a greater effect on the absorption of tolbutamide than of valproate. According to these findings and preliminary in vitro studies on other sulphonylureas high doses of activated charcoal can be recommended for the preventing the absorption of sulphonylureas in acute intoxications. The poor aqueous solubility of these substances at the gastric pH probably delays their gastrointest...Continue Reading

References

May 31, 1978·European Journal of Clinical Pharmacology·P J NeuvonenE Elonen
Jan 1, 1975·Clinical Toxicology·J W Hayden, E G Comstock
May 1, 1967·American Journal of Diseases of Children·A H Abdallah, A Tye
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Oct 1, 1981·Journal of Pharmaceutical Sciences·G Raghow, M C Meyer
Jan 1, 1980·European Journal of Clinical Pharmacology·P J Neuvonen, E Elonen

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Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·P J NeuvonenO Tokola
Nov 1, 1990·British Journal of Clinical Pharmacology·K T Kivistö, P J Neuvonen
Jan 1, 1997·British Journal of Clinical Pharmacology·A al-ShareefP A Routledge
Jun 21, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jeannie M Padowski, Gary M Pollack
Jan 1, 1984·Drug Metabolism Reviews·Z H Israili, P G Dayton
Jan 1, 1986·Journal of Toxicology. Clinical Toxicology·J A CordonnierA M Heyndrickx
Apr 13, 2005·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·P A ChykaUNKNOWN European Association of Poisons Centres and Clinical Toxicologists
Jul 9, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Anthony S ManoguerraUNKNOWN American Association of Poison Control Centers
Oct 12, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Lotte Christine Groth HoegbergHelle Riis Angelo
Jan 1, 1988·Medical Toxicology and Adverse Drug Experience·P J Neuvonen, K T Olkkola
Feb 12, 2017·Pharmacological Reports : PR·Wojciech JawieńWojciech Piekoszewski
Jan 1, 1990·The Journal of International Medical Research·F PisaniR Di Perri
Aug 24, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Lotte C G HoegbergSophie Gosselin

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