PMID: 19943496Dec 1, 2009Paper

Effect of active site of Xiangsha Liujunzitang on behavior and injury of hippocampal neurons in depression model mice

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Benhong ZhouFuwei Huang

Abstract

To observe the effect of the active site of Xiangshia Liujunzitang on behavior, injury of hippocampal neurons and Ca2+ ion in hippocampal synaptic in the depression model mice. Sixty male Kunming mice were randomly divided into 5 group, the control group, the model group and the active site of Xiangshia Liujunzitang groups (400, 600, 800 mg x kg(-1) body weight). The model was established by separation and chronic unpredictable mild stimulation. The increased weight and crossing scores, rearing scores were measured by open-field and sweet water consumption of mice. Cone cell and configuration of neuron in CA1, CA3 region of hippocampus were observed by Nissl. The concentration of Hippocampal synaptic Ca2+ was detected by fluorimetry. Comparing with the mice of control, the increased weight was slowed (P < 0.001), the scores of rearing and crossing were decreased (P < 0.001), sweet water consumption were decreased, too. Numbers of cone cells in CA3 region of hippocampus were decreased obviously (P < 0.001), and Ca2+ ion in hippocampal synaptic was increased obviously. Comparing with the mice of model, the active site of Xiangshia Liujunzitang could increase the increased weight on the 14 th and 21 st day obviously. The active si...Continue Reading

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