Effect of Acupuncture at LR3 on Cerebral Glucose Metabolism in a Rat Model of Hypertension: A 18 F-FDG-PET Study

Evidence-based Complementary and Alternative Medicine : ECAM
Jing LiXin-Sheng Lai

Abstract

Our objective was to investigate the effect of acupuncture at LR3 on cerebral glucose metabolism in spontaneously hypertensive rats (SHRs). We used 18F-2-fluoro-deoxy-D-glucose positron emission tomography (18F-FDG-PET) to examine the effects of acupuncture at LR3 on cerebral glucose metabolism in SHRs. SHRs were randomly allocated to receive no treatment (SHR group), needling at LR3 (SHR + LR3 group), or sham needling (SHR + sham group). Rats received 10 min acupuncture once per day for 7 days and were compared to normotensive Wistar Kyoto (WKY) rats. Blood pressure (BP) measurement and PET were performed after the first needling and the 7-day treatment period. BP was lower in the SHR + LR3 group compared to the other SHR groups between 30 and 60 min after the first needling and at 24 and 48 h after the 7-day treatment period. Glucose metabolism in the motor, sensory, and visual cortices was decreased in SHR group compared to WKY group. Needling at LR3 was associated with decreased glucose metabolism in the dorsal thalamus, thalamus, and hypothalamus and with increased metabolism in the cerebellar anterior and posterior lobes, medulla oblongata, and sensory cortex compared to the SHR group. These findings suggest that LR3 acup...Continue Reading

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Citations

Apr 16, 2019·International Journal of Hypertension·Juan LiFanrong Liang
Mar 25, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Si-Ming MaCun-Zhi Liu
Jul 10, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Lu WangCun-Zhi Liu

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Methods Mentioned

BETA
imaging technique
chip

Software Mentioned

spmratIHEP
SPSS
SPM8

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