PMID: 22574564May 12, 2012Paper

Effect of acupuncture on expression of brain-derived neurotrophic factor gene and protein in frontal cortex and hippocampus of depression rats

Zhen ci yan jiu = Acupuncture research
Jia LiangYa Tu

Abstract

To observe the influence of acupuncture of "Baihui" (GV 20) to "Yintang" (EX-HN 3) and unilateral "Neiguan" (PC 6) on the expression of brain-derived neurotrophic factor (BDNF) gene and protein in the prefrontal cortex and hippocampus in chronic stress-induced depression rats. Sprague-Dawley rats were randomly divided into four groups (6 rats/group): control, control + acupuncture, model, and model + acupuncture. Depression model was established by giving the rats with repeated abstinence of food and water, illumination at night, forced cold water-swimming, vibration, tail-clamping, constraint and raising alone for 28 days. Acupuncture was applied to "Baihui" (GV 20) to "Yintang" (EX-HN 3) and unilateral "Neiguan"(PC 6) once every other day for 28 days. The expression levels of BDNF mRNA and protein of the frontal cortex and hippocampus tissues were detected by real-time fluorescence quantitative PCR and Western blot methods, separately. Compared with the control group, the expression levels of BDNF mRNA and protein in the prefrontal cortex and hippocampus were significantly decreased in the model group (P < 0.01, P < 0.05). Whereas compared with the model group, BDNF mRNA and protein expression levels in the prefrontal cortex ...Continue Reading

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