Effect of acute and chronic administration of methylphenidate on mitochondrial respiratory chain in the brain of young rats.

Neurochemical Research
Ana O FagundesEmilio L Streck

Abstract

Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of chronic administration of methylphenidate on the activities of mitochondrial respiratory chain complexes I and III in the brain of young rats. The effect of acute administration of methylphenidate on mitochondrial respiratory chain complexes I, II, III and IV in the brain of young rats was also investigated. For acute administration, a single injection of methylphenidate was given to rats on postnatal day 25. For chronic administration, methylphenidate injections were given starting at postnatal day 25 once daily for 28 days. Our results showed that complexes I and III were not affected by chronic administration of methylphenidate. Moreover, the acute administration of methylphenidate decreased complex I activity in cerebellum and prefrontal cortex, whereas complexes II, III and IV were not altered.

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Citations

Sep 11, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Thomas LemppEllen Niederberger
Jan 21, 2014·Neuropharmacology·Joana GonçalvesAna Paula Silva
Apr 17, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sara Loureiro-VieiraJoão Paulo Capela
Jul 20, 2019·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L HolperJ J Mann
Feb 9, 2021·International Journal of Psychiatry in Clinical Practice·Hakan ÖğütlüOnur Burak Dursun
May 18, 2021·Neuroscience and Biobehavioral Reviews·Tim L EmmerzaalTamas Kozicz
Feb 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sara Loureiro-VieiraJoão Paulo Capela

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