PMID: 8959020Oct 31, 1996Paper

Effect of acute and chronic administration of methamphetamine on activator protein-1 binding activities in the rat brain regions

Annals of the New York Academy of Sciences
K AkiyamaK Kashihara

Abstract

The activator protein-1 (AP-1) binding activities in the three brain regions (striatum, nucleus accumbens, cingulate cortex) increased after a single methamphetamine (METH, 4 mg/kg) injection and reached maximum levels after 180 min. Pretreatment with SCH 23390 (0.5 mg/kg), a selective dopamine D1 receptor antagonist, significantly inhibited the enhanced AP-1 binding activities induced by acute METH (4 mg/kg) administration. In chronic experiments, rats were pretreated with METH (4 mg/kg) or saline for 14 days. The AP-1 binding activities after a 1-week abstinence from chronic administration of MAP increased significantly in all the brain regions compared with those of the saline-treated controls, whereas after a 4-week abstinence, the AP-1 binding activity decreased significantly in the cingulate cortex, but not striatum or nucleus accumbens, compared with the saline-treated control group. A METH challenge after a 4-week abstinence period induced significantly more intense stereotypy, but lower AP-1 binding activities in all the brain regions of rats treated with repeated METH than repeated saline injections. The super-shift assay revealed that after a 1- or 4-week abstinence, there was no significant difference between the Fo...Continue Reading

References

Jan 1, 1992·Schizophrenia Bulletin·M SatoT Hamamura
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B HopeE J Nestler
Dec 10, 1991·Biochimica Et Biophysica Acta·P Angel, M Karin
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M GraybielH A Robertson

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Citations

Sep 19, 2002·Journal of Neuroscience Research·Yong Woo LeeMichal Toborek
Jan 6, 2005·Developmental Psychobiology·Romana SlamberováMarie Pometlová
Apr 6, 2005·Reproductive Toxicology·Romana SlamberováMarie Pometlová
Sep 1, 2015·Frontiers in Cellular Neuroscience·Katherine ConantSeung T Lim

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