PMID: 36324Jan 1, 1979

Effect of acute and chronic ethanol administration on the content of coenzymes linked to energy transfer in the liver of rats fed standard or low-protein diet

Gastroenterologia Japonica
H KonoG A Martini


1) In rats fed a standard diet or a protein restricted diet the effect of acute and chronic ethanol administration on liver content of adenine nucleotides was studied. In the long-term experiments the total liver content of NAD and NADP was additionally determined. 2) a single oral ethanol load does not significantly influence the total adenine nucleotide content. Liver AMP content increases immediately following ethanol ingestion about 2-fold and remains elevated for 12 hours. ATP content and ATP/ADP ratio are significantly reduced within 30 minutes after ethanol administration. Both return to initial values after 2 hours adn decrease again thereafter. 3) The increase in the AMP content is dose dependent, i.e. it is more pronounced after small doses of ethanol and is not observed when blood ethanol concentrations are very high. The elevation of the AMP levels during ethanol oxidation is interpreted as a consequence of increased ATP consumption and of inhibition of citric acid cycle. 4) In animals fed nearly protein-free diet, total adenine nucleotide content and ATP content are distinctly reduced. An increase in AMP concentration is not observed in these rats where ethanol oxidation is markedly inhibited. 5) Chronic ethanol ap...Continue Reading


Nov 15, 1971·Klinische Wochenschrift·C Bode, H Goebell
Jan 1, 1967·Annual Review of Medicine·C S Lieber
Aug 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·E A NIKKILAE, K OJALA
Dec 19, 1964·Nature·D E HYAMS, K J ISSELBACHER
Sep 15, 1951·Klinische Wochenschrift·T BUCHER, H REDETZKI


Oct 4, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Suthat LiangpunsakulDavid W Crabb
May 27, 2009·International Journal of Molecular Sciences·Petras Dzeja, Andre Terzic

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