PMID: 1202255Oct 11, 1975Paper

Effect of acute and chronic metabolic acidosis on serum immunoreactive parathyroid hormone in man

Kidney International
F L CoeE Reiss

Abstract

The effects of acute and chronic metabolic acidosis on serum immunoreactive parathyroid hormone (iPTH) were studied. Acute metabolic acidosis induced by administration of ammonium chloride (NH4Cl) produced a barely detectable increase in serum iPTH. Chronic NH4Cl administration produced a marked elevation of serum iPTH that was well correlated with the magnitude of acid-induced hypercalciuria but not with the degree of acidosis. Acetazolamide administration produced an equivalent degree of acidosis, but hypercalciuria was minimal and iPTH increased only marginally. Methionine administration caused moderate hypercalciuria and a significant but moderate increase in iPTH. Chronic NH4Cl-induced acidosis produced no hypercalciuria when dietary sodium intake was rigidly restricted, and under these conditions serum iPTH remained normal. When sodium intake was suddenly increased while maintaining the acid load, hypercalciuria appeared and was followed by progressive rise in serum iPTH equivalent to that observed during chronic NH4Cl-induced acidosis in subjects consuming salt ad lib. These results indicate that chronic acidosis elevates iPTH mainly by producing hypercalciuria and that acidosis itself is not a primary stimulus to PTH se...Continue Reading

References

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Citations

Nov 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T R Arnett, D W Dempster
Oct 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E L Chan, R Swaminathan
Jan 1, 1982·International Urology and Nephrology·Z SzendröiL Kiss
Jan 1, 1989·Calcified Tissue International·H Freudiger, J P Bonjour
Jan 1, 1992·Biological Trace Element Research·A CaldasC Kleinknecht
Jun 8, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey A Kraut, Nicolaos E Madias
May 27, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hsin-Yun TsaiJeng-Daw Tsai
Oct 1, 1977·Metabolism: Clinical and Experimental·B E BoothR C Morris
Mar 7, 2001·Kidney International·S DomrongkitchaipornR Rajatanavin
Jan 12, 1978·The New England Journal of Medicine
Sep 6, 1979·The New England Journal of Medicine·H L BleichR W Gray
Jan 1, 1990·Nutrition Research Reviews·C Shortt, A Flynn
May 1, 1993·British Journal of Urology·M J Gleeson, D P Griffith
Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ignacio LopezMariano Rodriguez
Feb 3, 2006·Scandinavian Journal of Urology and Nephrology·Palle J Osther
May 24, 2001·The American Journal of the Medical Sciences·M Thierry-PalmerN Donkoh
May 11, 2005·Kidney International. Supplement·Joel D KoppleRajnish Mehrotra
Apr 1, 1984·Kidney International·J A KrautK Kurokawa
Dec 1, 1989·Kidney International·A LefebvreC Morieux
Sep 3, 2010·Kidney International·Dagmara BorzychUNKNOWN International Pediatric PD Network (IPPN)
Jun 1, 1995·Kidney International·D A Bushinsky
Sep 1, 1982·Kidney International·D BatlleN A Kurtzman
Sep 1, 1982·Kidney International·D A BushinskyJ H Parks
Nov 1, 1986·Kidney International·J A KrautW G Goodman
Nov 1, 1983·Kidney International·I KurtzA Sebastian
Jan 1, 1991·Kidney International·J Green, C R Kleeman
Feb 12, 2004·Kidney International. Supplement·Rajnish MehrotraMarsha Wolfson
Aug 1, 1979·Metabolism: Clinical and Experimental·R MahnensmithR A DeFronzo
Dec 1, 1984·European Journal of Clinical Investigation·S LjunghallG Akerstrom
May 1, 1997·The Journal of Urology·J A HochstetlerK J Kreder
Nov 1, 1976·Clinical Pediatrics·J C Chan

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