Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration

Endocrinology
Raimund I HerzogRobert S Sherwin

Abstract

Our objective was to evaluate whether excessive brain glycogen deposition might follow episodes of acute hypoglycemia (AH) and thus play a role in the hypoglycemia-associated autonomic failure seen in diabetic patients receiving intensive insulin treatment. We determined brain glucose and glycogen recovery kinetics after AH and recurrent hypoglycemia (RH), an established animal model of counterregulatory failure. A single bout of insulin-induced AH or RH for 3 consecutive days was used to deplete brain glucose and glycogen stores in rats. After microwave fixation and glycogen extraction, regional recovery kinetics in the brain was determined using a biochemical assay. Both AH and RH treatments reduced glycogen levels in the cerebellum, cortex, and hypothalamus from control levels of 7.78 +/- 0.55, 5.4 +/- 0.38, and 4.45 +/- 0.37 micromol/g, respectively, to approximately 50% corresponding to a net glycogen utilization rate between 0.6 and 1.2 micromol/g.h. After hypoglycemia, glycogen levels returned to baseline within 6 h in both the AH and the RH group. However, recovery of brain glycogen tended to be faster in rats exposed to RH. This effect followed more rapid recovery of brain glucose levels in the RH group, despite simila...Continue Reading

References

Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M R Davis, H Shamoon
May 28, 1987·The New England Journal of Medicine·S A AmielR S Sherwin
Aug 1, 1974·Analytical Biochemistry·J V Passonneau, V R Lauderdale
Jun 1, 1981·Journal of Neurochemistry·R A RatchesonJ A Ferrendelli
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C D AgardhB K Siesjö
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·P J BoyleC Qualls
Feb 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I CranstonS A Amiel
Aug 8, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I Y ChoiR Gruetter
May 22, 2002·Neurochemistry International·Rolf Gruetter
Dec 7, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nancy F Cruz, Gerald A Dienel
Mar 20, 2003·Journal of Neuroscience Research·In-Young ChoiRolf Gruetter
May 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul FrankenH Craig Heller
May 14, 2003·Neurochemistry International·Gülin OzRolf Gruetter
Sep 30, 2003·Journal of Neuroscience Research·Rolf Gruetter
Apr 17, 2004·Journal of Neurochemistry·Angus M Brown
May 28, 2004·The New England Journal of Medicine·Philip E Cryer
Nov 24, 2004·Metabolic Brain Disease·Roland N Auer
Mar 1, 2005·Nature Medicine·Tony K T LamLuciano Rossetti
Sep 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Martin G de VriesJ Lee Beverly
Mar 4, 2006·Neurochemistry International·Gerald A Dienel, Nancy F Cruz
Mar 9, 2006·Neurochemistry International·Florence D MorgenthalerRolf Gruetter
Apr 29, 2006·Neuroscience Letters·Paul FrankenH Craig Heller
Jul 13, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Leif HertzGerald A Dienel
Aug 1, 2006·Progress in Brain Research·Philip E Cryer
Jan 30, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hongxia LeiRolf Gruetter
Jul 31, 2007·Glia·Luc PellerinPierre J Magistretti
Jul 31, 2007·Glia·Angus M Brown, Bruce R Ransom

❮ Previous
Next ❯

Citations

Mar 19, 2013·Journal of Bioenergetics and Biomembranes·Susana CardosoPaula I Moreira
Jul 26, 2013·The New England Journal of Medicine·Philip E Cryer
Mar 8, 2012·Reproduction, Fertility, and Development·Olivier SandraRichard G Lea
Jun 4, 2010·Antioxidants & Redox Signaling·Xavier FioramontiVanessa H Routh
Apr 28, 2011·The Journal of Physiology·Takashi MatsuiHideaki Soya
Jan 10, 2013·The Journal of Clinical Investigation·Kim C C van de VenBastiaan E de Galan
May 23, 2012·ASN Neuro·Gerald A Dienel
Mar 29, 2014·Metabolic Brain Disease·Ameer KhowajaGülin Öz
Feb 12, 2014·Metabolic Brain Disease·Gerald A Dienel, Nancy F Cruz
Nov 9, 2011·The Journal of Physiology·Takashi MatsuiHideaki Soya
Nov 2, 2015·Cellular and Molecular Life Sciences : CMLS·Hanne M M RooijackersBastiaan E de Galan
Feb 9, 2013·Endocrinology and Metabolism Clinics of North America·Candace M RenoSimon J Fisher
Aug 9, 2011·Metabolism: Clinical and Experimental·Min Jung ParkGregory G Freund
Jan 26, 2010·Physiology & Behavior·Ewan C McNay, Victoria E Cotero
Nov 3, 2010·Annals of the New York Academy of Sciences·Nolawit Tesfaye, Elizabeth R Seaquist
Jan 25, 2011·Journal of Neuroscience Research·Sarah E CanadaBartholomew A Pederson
Jan 17, 2014·Journal of Neuroendocrinology·V F H JensenJ Lykkesfeldt
Oct 2, 2015·Aging and Disease·João M N Duarte
Sep 8, 2015·Molecular Aspects of Medicine·Jordi Duran, Joan J Guinovart
May 10, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A M BlancoM Aldegunde
Mar 13, 2012·Neurobiology of Aging·Yoo Young HoogendamM Arfan Ikram
Jul 30, 2009·Diabetes Care·Rory McCrimmon
Sep 30, 2010·Diabetes·Rory J McCrimmon, Robert S Sherwin
Jun 9, 2009·Diabetes·Gülin OzElizabeth R Seaquist
Nov 3, 2016·The Physician and Sportsmedicine·Valentina PerciavalleMarinella Coco
Nov 12, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gülin ÖzElizabeth R Seaquist
Oct 6, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gülin ÖzElizabeth R Seaquist
Oct 18, 2018·Diabetes·Janice J HwangRobert S Sherwin
Apr 11, 2018·Molecular Neurobiology·Ashish K Rehni, Kunjan R Dave
Jan 29, 2019·Endocrine Reviews·Sarah StanleyElizabeth R Seaquist
May 3, 2019·Journal of Neuroendocrinology·Alastair J MacDonaldKate L J Ellacott
May 3, 2019·Journal of Neuroscience Research·Ana Francisca SoaresJoão M N Duarte

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.