PMID: 6414110Jun 1, 1983Paper

Effect of acute and repeated selenium treatment on hepatic monooxygenase enzyme activity in male rats

Toxicology Letters
R C SchnellM H Davies

Abstract

The effect of sodium selenite administered acutely or repeatedly on the biochemical components of the hepatic microsomal monooxygenase enzyme system was examined in male rats. 72 h following acute administration of selenium (2.4 mg Se/kg, i.p.), there was a significant decrease in ethylmorphine-N-demethylase activity and cytochrome P-450 levels but no change in aniline hydroxylase or NADPH cytochrome c reductase activity. Following repeated administration of selenite in the drinking water (1, 2, or 4 ppm Se) for 30 days, there was no alteration in any of the parameters measured. Following the in vitro additions of selenite to microsomes obtained from untreated rats, ethylmorphine-N-demethylase and aniline hydroxylase activities were inhibited at selenium concentrations of 10(-4) M or greater, but the inhibition achieved was less than 50%. No alterations in cytochrome P-450 levels were observed. These results indicate that selenium is a rather weak, indirect, and substrate-specific inhibitor of the hepatic monooxygenase enzyme system.

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Feb 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·P L WRIGHT, F R MRAZ

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Citations

Jan 1, 1984·Toxicology and Applied Pharmacology·B A MerrickR C Schnell
Jan 1, 1993·Drug and Chemical Toxicology·K Nagamatsu, A Hasegawa
Aug 1, 1988·Toxicology and Applied Pharmacology·R C SchnellS W Weir

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