Effect of acute cocaine administration on the QTc interval of habitual users

The American Journal of Cardiology
Anthony R MagnanoHasan Garan

Abstract

The proarrhythmic effects of cocaine may be mediated in part by its effects on cardiac repolarization properties. This study evaluated the acute effects of smoking cocaine 25 mg on the electrocardiograms of 14 habitual cocaine users during a 12-minute observation period. After cocaine administration, heart rate increased by a mean of 22 beats/min (p <0.0001). One patient developed accelerated junctional rhythm, and 5 had nonspecific ST-T-wave abnormalities. The electrocardiograms revealed significant prolongation of the QTc interval (p <0.001) after cocaine administration. In addition, T-wave amplitude decreased and U-wave amplitude increased in response to cocaine use (p <0.05). QRS duration was unchanged by cocaine, whereas the PR interval shortened slightly. The repolarization changes observed after cocaine use were similar to those reported for other sympathomimetic agents and may be a contributing factor in the association between cocaine use and ventricular arrhythmias.

References

Mar 1, 1990·Biophysical Journal·W J Crumb, C W Clarkson
Oct 1, 1990·Drug and Alcohol Dependence·R W FoltinG D Pearlson
Feb 1, 1988·Archives of Internal Medicine·J R RaymondM J Knapp
Aug 15, 1995·The American Journal of Cardiology·W C DanielR A Lange
Jan 1, 1996·The American Journal of Emergency Medicine·S B Karch
Jul 26, 2000·The American Journal of the Medical Sciences·G A GamourasL S Dreifus
Jun 1, 2002·Journal of the American College of Cardiology·Anthony R MagnanoDaniel M Bloomfield
Feb 18, 2003·European Journal of Clinical Investigation·S LeeS R Heller
May 4, 2004·Trends in Cardiovascular Medicine·Dan M Roden
Nov 18, 2004·Pacing and Clinical Electrophysiology : PACE·Anthony R MagnanoDaniel M Bloomfield
May 14, 2005·Journal of Electrocardiology·Anthony R MagnanoDaniel M Bloomfield

❮ Previous
Next ❯

Citations

Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Stella C Wong, James R Roberts
Aug 28, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kristopher J BoughF Gerard Moeller
May 8, 2013·Journal of Addiction Medicine·Thomas S AtkinsonAlison Oliveto
Jun 25, 2009·Nuclear Medicine Communications·Esa KauppilaJyrki Kuikka
Jan 1, 2008·Primary Care Companion to the Journal of Clinical Psychiatry·David W AbramsonTheodore A Stern
Apr 25, 2014·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Alicia M MaceiraDudley J Pennell
Jul 22, 2010·Pharmaceuticals·Thierry Favrod-Coune, Barbara Broers
Dec 17, 2015·The Journal of Pharmacology and Experimental Therapeutics·Vishakantha MurthyStephen Brimijoin
Sep 26, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·David M WoodRobert S Hoffman
Oct 6, 2009·Drug and Alcohol Dependence·Susan K WoodJames H Woods
Jun 25, 2010·British Journal of Clinical Pharmacology·Michael E O'Leary, Jules C Hancox
Oct 10, 2006·The American Journal of Cardiology·Mori J KrantzJohn Schmittner
Aug 2, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Francesco FurlanelloLuigi De Ambroggi
Oct 30, 2013·Therapeutic Advances in Psychopharmacology·W Victor R ViewegAnanda K Pandurangi
Jul 17, 2013·Journal of Cardiovascular Medicine·Matteo AnselminoFiorenzo Gaita
Dec 14, 2011·Expert Review of Cardiovascular Therapy·F Daniel RamirezAdrian Baranchuk
Feb 10, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Ulf K RadunskiKai Muellerleile
Sep 29, 2020·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Alicia M MaceiraJose Salazar
Oct 9, 2020·Case Reports in Cardiology·Weng-Chio TamMario Alberto De Brito Lima Evora
Feb 11, 2021·Clinics and Practice·Karthik GnanapandithanJaime Gerber

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.