PMID: 7542933May 1, 1995Paper

Effect of acute glucose antagonism on hypophyseal hormones and concentrations of insulin-like growth factor (IGF)-I and IGF-binding proteins in serum, anterior pituitary, and hypothalamus of ewes

Biology of Reproduction
R N FunstonG E Moss

Abstract

The objectives of this study were to determine whether 2-deoxy-D-glucose (2DG), a metabolic inhibitor of glucose, 1) differentially affected release of LH, growth hormone (GH) and prolactin (PRL); 2) decreased anterior pituitary response to GnRH; and 3) altered concentrations of insulin-like growth factor I (IGF-I) and intensity of 125I-IGF-I binding to proteins (IGFBPs) in serum, anterior pituitary (AP), and hypothalamus (preoptic are [POA], medial basal hypothalamus [MBH], and stalk median eminence [SME]). In trial 1, mature, ovariectomized, crossbred ewes were treated with a single s.c. injection of either saline (n = 5) or 2DG (n = 5; 0.1 g/kg BW). Administration of 2DG suppressed (p < 0.05) concentrations of LH but did not affect (p > 0.05) serum concentrations of GH or PRL. In trial 2, ovariectomized ewes received injections of saline or 2DG, and each group was subdivided to receive either saline or GnRH analog (5 micrograms; Des-Gly10-[D-Ala6]) 2 h later. Administration of 2DG suppressed (p < 0.05) serum concentrations of LH before administration of GnRH; however, release of LH in response to exogenous GnRH was greater (p < 0.05) in ewes that received 2DG. Treatment with 2DG did not affect (p > 0.05) concentrations of FS...Continue Reading

Citations

Jun 6, 2002·Animal Reproduction Science·Christina J McManusBarry P Fitzgerald
Jul 17, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·B K CampbellR J Scaramuzzi
Aug 24, 2013·Reproduction in Domestic Animals = Zuchthygiene·J A DanielJ L Sartin
Jul 11, 2006·Reproduction, Nutrition, Development·Dominique BlacheGraeme B Martin
Sep 28, 2004·Journal of Animal Science·Z KiymaG E Moss
May 26, 2009·Journal of Animal Science·E J ScholljegerdesG E Moss
Aug 13, 1999·The American Journal of Physiology·C A JaffeR Demott-Friberg

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