Effect of acute hyperglycaemia, long-term glycaemic control and insulin on endothelial dysfunction and inflammation in Type 1 diabetic patients with different characteristics

Diabetic Medicine : a Journal of the British Diabetic Association
Antonio CerielloDario Giugliano

Abstract

To investigate the possibility of reversing endothelial dysfunction and inflammation by glucose normalization, antioxidants and insulin per se, in different subgroups of Type 1 diabetic patients. Three subgroups of Type 1 diabetic patients were studied: patients within 1 month of diagnosis (subgroup 1); patients with approximately 5 years' disease duration and with glycated haemoglobin (HbA(1c)) <or= 7.0% (subgroup 2) or > 7.0% since diagnosis (subgroup 3). Participants underwent four procedures: 2-h hyperglycaemic clamp followed by: (A) 12 h near-normalization of blood glucose, with the addition of vitamin C during the last 6 h; (B) 12-h vitamin C and near-normalization of blood glucose for the last 6 h; (C) both vitamin C and near-normalization of blood glucose for 12 h; (D) hyperglycaemic-hyperinsulinaemic clamp for 12 h, with the addition of vitamin C during the last 6 h. After 2 h of hyperglycaemia, markers of endothelial dysfunction, nitrotyrosine, 8-iso prostaglandin F2alpha, soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, interleukin (IL)-6 and IL-18 were increased in all the subgroups. Levels were normalized, at all time points, by treatments A, B and C in the subgroups 1 and 2. In the ...Continue Reading

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Jun 6, 2009·The Journal of Clinical Endocrinology and Metabolism·Antonio CerielloDario Giugliano

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Citations

Dec 3, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·N ColomoM S Ruiz de Adana
Dec 10, 2016·Journal of Neuroinflammation·Eun-Ah YeJena J Steinle
Feb 11, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Markolf HanefeldDavid Owens
May 31, 2020·Diabetes Care·Jasna Šuput OmladičTadej Battelino
Dec 21, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·B J Boucher
Dec 30, 2020·Nutrients·Charles WattJanice Jin Hwang
Apr 1, 2018·Canadian Journal of Diabetes·Mallory L DownieDamien G Noone

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