Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy

European Journal of Clinical Investigation
J B FrøkjaerAsbjørn M Drewes

Abstract

Acute hyperglycaemia is known to increase gastrointestinal (GI) sensitivity in healthy subjects and may contribute to the increased prevalence of GI symptoms in diabetes patients. The aim of this study was to evaluate the effect of acute hyperglycaemia on perception and brain responses to painful visceral and somatic stimuli in diabetic patients. The sensitivity and evoked brain potentials (EPs) to electrical oesophageal and median nerve stimulations were assessed in 14 type-1 diabetes patients with autonomic neuropathy and GI symptoms using a hyperinsulinaemic clamp at 6 and 15 mM. No differences between the normo- and hyperglycaemic conditions were found in sensitivity to both oesophageal (P=0·72) and median nerve (P=0·66) stimulations. The latencies and amplitudes of EPs did not differ between the normo- and hyperglycaemic conditions following oesophageal (P=0·53 and 0·57) and median nerve (P=0·78 and 0·52) stimulations. Acute hyperglycaemia itself does not contribute to the sensations in patients with longstanding diabetes and autonomic neuropathy. Any potential sensory effects of acute hyperglycaemia can likely be blurred by the neuropathic-like changes in the sensory nervous system.

References

Jul 1, 1984·The American Journal of Medicine·G K MorleyJ E Morley
Mar 1, 1996·European Journal of Gastroenterology & Hepatology·G S HebbardM Horowitz
Feb 7, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G E BoeckxstaensR H Holloway
Mar 4, 1999·Digestive Diseases and Sciences·C K RaynerM Horowitz
Jun 3, 1999·European Journal of Clinical Investigation·A RussoW M Sun
May 16, 2000·The American Journal of Gastroenterology·C K RaynerM Horowitz
Feb 27, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·A RussoW-M Sun
Apr 25, 2006·Neuroscience·S A K SamiA M Drewes
Apr 6, 2007·Gastroenterology·Georg DimcevskiAsbjørn M Drewes
Apr 16, 2009·Diabetes Care·Jens Brøndum FrøkjaerAsbjørn Mohr Drewes
Jan 9, 2010·European Journal of Clinical Investigation·I SimeraD G Altman

❮ Previous
Next ❯

Citations

Jun 29, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J B FrøkjaerH Gregersen
Aug 20, 2014·Journal of Diabetes Research·Eirik SøftelandGeorg Dimcevski
Dec 21, 2013·Journal of Diabetes and Its Complications·Eirik SøftelandGeorg Dimcevski
Mar 6, 2012·Diabetes Research and Clinical Practice·João Xavier JorgeCarlos Costa Almeida
Oct 28, 2016·Annals of the New York Academy of Sciences·Jingbo Zhao, Hans Gregersen
Mar 10, 2017·Clinical and Translational Gastroenterology·Mirjam HiestandDonald O Castell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Eirik SøftelandJens Brøndum Frøkjær
European Journal of Pain : EJP
Jens Brøndum FrøkjærAsbjørn M Drewes
© 2021 Meta ULC. All rights reserved