PMID: 9188761Jan 1, 1997Paper

Effect of acute hyperglycemia on basal and cholecystokinin stimulated exocrine pancreatic secretion in humans

Life Sciences
W F lamC B Lamers

Abstract

This study was undertaken to investigate the effect of acute hyperglycemia on pancreatico-biliary secretion in healthy subjects. Duodenal outputs of bilirubin, amylase, trypsin and bicarbonate were measured by aspiration using a recovery marker under basal condition for 75 min and during continuous infusion of CCK (0.5 IDU/kg.h for 60 min). Seven healthy subjects participated in two experiments performed in random order during normoglycemia and during acute hyperglycemic clamping at 15 mmol/l. At regular intervals plasma PP levels were determined as an indirect measure of vagal-cholinergic tone. Basal pancreatico-biliary secretion was significantly (p<0.05) reduced during acute hyperglycemia. CCK significantly (p<0.05) increased bilirubin, amylase and trypsin output both during normo- and hyperglycemia. During the initial 30 min of CCK infusion the bilirubin, amylase and trypsin outputs were significantly (p<0.05) inhibited in the hyperglycemic experiment compared to normoglycemia. In the following 30 min of CCK infusion the bilirubin, amylase and trypsin output were not different between hyper- and normoglycemia. Basal and CCK-stimulated plasma PP concentrations were significantly (p<0.05) reduced during hyperglycemia. In summ...Continue Reading

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Citations

May 26, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·L GianottiUNKNOWN ESPEN
Jun 20, 2006·Best Practice & Research. Clinical Gastroenterology·Rémy F Meier, Christoph Beglinger
Jun 12, 2002·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·R MeierUNKNOWN ESPEN Consensus Group
Sep 22, 2005·Scandinavian Journal of Gastroenterology·Tomas SymerskyAd A M Masclee

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