Effect of acute hypoxia on the pulmonary conversion of angiotensin I to angiotensin II in dogs

Circulation Research
P SzidonS Oparil

Abstract

We studied the effect of acute hypoxia on pulmonary conversion of angiotensin I to II in anesthetized dogs. When arterial PO2 was decreased from 86 +/- 14 (SD) to 33 +/- 8 mm Hg without changing pH or PCO2, the single passage conversion of intravenous boluses of radiolabeled angiotensin I in tracer doses fell significantly (P less than 0.005) from 72 +/- 4 to 67 +/- 6%. The effect of comparable levels of hypoxemia on the conversion of continuous intravenous infusions of pharmacological doses (1000 times physiological) of angiotensin I was greater: from 55 +/- 14 to 33 +/- 13% (P less than 0.025). There was prompt return of percent conversion ratios to control levels when hypoxemia was reversed. We conclude that acute hypoxia is associated with a reversible decrease in pulmonary angiotensin converting enzyme availability.

References

Feb 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S A StalcupR B Mellins
May 1, 1979·The Journal of Clinical Investigation·S A StalcupR B Mellins
Sep 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·P J LeuenbergerG M Turino
Jul 1, 1976·Journal of Applied Physiology·J M AlexanderK A Jasberg
Feb 1, 1969·The Journal of Clinical Endocrinology and Metabolism·L B PageA Purnode
Sep 1, 1973·Journal of Applied Physiology·B L Fanburg, J B Glazier
Oct 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·A MolteniL Mattioli
Jan 1, 1960·Journal of Applied Physiology·W R MILNOR, A D JOSE

Citations

Jan 1, 1987·Annals of Biomedical Engineering·B R PittL M Reid
Jan 1, 1985·Lung·A B MalikK E Burhop
Jan 1, 1981·Lung·J A Pang, D M Geddes
Jul 1, 1985·Canadian Anaesthetists' Society Journal·J K AlifimoffD R Cook
Jan 1, 1985·Clinical and Experimental Pharmacology & Physiology·H RaffI A Reid
Sep 2, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Brian E HuntJ Woodrow Weiss
Apr 1, 1990·Journal of Pharmacological Methods·L MorM B Youdim
Feb 1, 1982·Chest·E R Block, S A Stalcup
Jan 1, 1982·Annals of the New York Academy of Sciences·S A StalcupR B Mellins
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Aug 13, 1999·The American Journal of Physiology·J BauerN Parekh

Related Concepts

Acute Disease
Angiotensin I
Angiotensin II, Val(5)-
Angiotensins
Metazoa
Anoxemia
Diastolic Blood Pressure
Carbon Dioxide
Cardiac Output
Canis familiaris

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