Effect of acute NR2B antagonist treatment on long-term potentiation in the rat hippocampus

Brain Research
John D GraefLinda J Bristow

Abstract

The long lasting antidepressant response seen following acute, i.v. ketamine administration in patients with treatment-resistant depression (TRD) is thought to result from enhanced synaptic plasticity in cortical and hippocampal circuits. Using extracellular field recordings in rat hippocampal slices, we show that a single dose of the non-selective NMDA receptor antagonist ketamine or CP-101,606, a selective antagonist of the NR2B subunit of the NMDA receptor, enhances hippocampal synaptic plasticity induced with high frequency stimulation (HFS) 24h after dosing - a time at which plasma concentrations of the drug are no longer detectable in the animal. These results indicate that acute inhibition of NMDA receptors containing the NR2B subunit can lead to long-lasting changes in hippocampal plasticity.

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Citations

Jun 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael R WeedLinda J Bristow
Jun 10, 2017·Expert Review of Neurotherapeutics·Gopalkumar RakeshPrakash S Masand
Feb 26, 2019·Frontiers in Neuroscience·Jinping LiuYan Wu
May 12, 2017·Neural Plasticity·Yu-Jhen HuangChieh-Hsin Lin
Jul 25, 2019·Neuroscience and Biobehavioral Reviews·Lily R AleksandrovaAnthony G Phillips
Feb 6, 2018·Neurobiology of Learning and Memory·Alessandro PivaCristiano Chiamulera
Nov 1, 2020·Current Opinion in Pharmacology·Cristiano ChiamuleraWickliffe C Abraham
Apr 28, 2021·Hippocampus·Rachel E KeithTheodore C Dumas
May 26, 2018·ACS Medicinal Chemistry Letters·Lawrence R MarcinJohn E Macor
Aug 28, 2021·International Journal of Molecular Sciences·Abdallah AhnaouWilhelmus H Drinkenburg

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