Effect of acyclovir on HIV-1 set point among herpes simplex virus type 2-seropositive persons during early HIV-1 infection.

The Journal of Infectious Diseases
H Nina KimConnie Celum

Abstract

We evaluated whether acyclovir suppression during human immunodeficiency virus type 1 (HIV-1) acquisition reduces HIV-1 set point, increases CD4 cell counts, and selects reverse-transcriptase mutations among 76 HIV-1 seroconverters identified in a placebo-controlled trial of twice-daily acyclovir (400 mg) for the prevention of HIV acquisition in herpes simplex virus type 2 (HSV-2)-seropositive persons (HIV Prevention Trials Network study 039). We found no significant difference in plasma HIV-1 RNA levels (P =.30) or CD4 cell counts (P =.85) between the acyclovir and placebo recipients. V75I and other mutations in HIV-1 reverse transcriptase reported from in vitro acyclovir studies were not observed. In conclusion, acyclovir suppression during HIV-1 seroconversion and the subsequent 6 months does not affect HIV-1 set point.

References

Apr 15, 1995·Annals of Internal Medicine·J W MellorsP Gupta
Dec 16, 1998·Annals of Internal Medicine·T W SchackerL Corey
Apr 3, 2007·The Journal of Infectious Diseases·Edward R CachaySusan J Little
Jun 11, 2009·The Journal of Biological Chemistry·Egor P TchesnokovMatthias Götte
Jan 22, 2010·The New England Journal of Medicine·C CelumUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team
Mar 11, 2010·The Journal of Infectious Diseases·Jonathan FuchsUNKNOWN HIV Prevention Trials Network 039 Protocol Team

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Citations

Jan 19, 2012·Sexually Transmitted Diseases·Myron S Cohen, Joseph J Eron
Jan 27, 2016·Current HIV/AIDS Reports·Michael L FreemanSara Gianella
Mar 10, 2015·The Journal of Infectious Diseases·Sara GianellaDavey M Smith
Mar 6, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christophe VanpouilleLeonid Margolis
Mar 15, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Amy MedleyUgochukwu Amanyeiwe
Feb 4, 2016·Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada·C R SmithTty Lau
Jan 1, 2013·Journal of Sexually Transmitted Diseases·Helen M ChunNancy F Crum-Cianflone
Feb 16, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rebecca G NowakPatti E Gravitt

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