Effect of adeno-associated virus-mediated transfer of low density lipoprotein receptor gene on treatment of hypercholesterolemia

Science in China. Series C, Life Sciences
G ChenJ Tang

Abstract

Low density lipoprotein receptor (LDL-R) plays an important role in removing LDL from plasma and preventing prbducing atherosclerosis. To test hepatic reconstitution of LDLR expression is sufficient for metabolic correction of subjects with hypercholesterolemia; a recombinant adeno-associated virus (rAAV) carrying the human LDL receptor cDNA (AAV/LDL-R) was constructed. Using adenosome, a complex of ademviral capsid protein and lipsome, to transfer the rAAV into livers of rabbits with experimental hypercholesterolemia could elicit the production of LDL-R and lower plasma cholesterol level. These results demonstrate that AAV-mediated transfer of LDL-R gene may provide an alternative means to gene therapy of hypercholesterolemia.

References

Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Herz, R D Gerard

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