Effect of adenosine 3',5'-cyclic monophosphate (cAMP) on human non-tumorigenic and tumorigenic parotid acinar cells in culture

Cancer Letters
G KrauseK N Prasad

Abstract

Adenosine 3',5'-cyclic monophosphate (cAMP) regulates growth and/or differentiation of some tumor cells in culture. The effects of cAMP on human parotid acinar cells have never been studied. Results showed that 2HPC8 (non-tumorigenic cells derived from human pleomorphic parotid adenoma) were more sensitive to dibutyryl cAMP, an analog of cAMP, and RO20-1724, an inhibitor of cyclic nucleotide phosphodiesterase, than 2HP1G cells (derived from spontaneous transformation of 2HPC8 cells), suggesting that human parotid adenoma cells maintain a higher degree of cAMP-responsiveness than parotid carcinoma cells. Prostaglandin E1 (PGE1), a stimulator of adenylate cyclase, which increased cAMP levels in 2HPC8 cells, but not in 2HP1G cells, caused a greater degree of growth inhibition in 2HP1G cells than in 2HPC8 cells, suggesting that this effect of PGE1 on tumorigenic cells is not related to cAMP. In the normal parotid and parotid adenoma cell cultures, about 5-10% of cells were small and round, whereas in tumorigenic cell cultures, all cells were small and round. Some indirect evidence suggests that these round cells may be the primary target for transformation. These tumor cells formed cytoplasmic processes of variable length after tre...Continue Reading

References

Nov 1, 1976·Journal of Oral Pathology·H M Fullmer
Nov 1, 1991·Biological Reviews of the Cambridge Philosophical Society·K N Prasad
Feb 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A W Hsie, T T Puck
Feb 1, 1971·Cancer·T KondoM Imaizumi
May 1, 1994·In Vitro Cellular & Developmental Biology. Animal·K N PrasadS Kentroti

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved