PMID: 2487371Jan 1, 1989Paper

Effect of adenosine in some models of inflammation and anaphylaxis in experimental animals

Archivum Immunologiae Et Therapiae Experimentalis
M L Arruzazabala, M Garcia

Abstract

Adenosine has controversial effects. The inhalation of this substance causes bronchoconstriction in asthmatic patients, but possesses a protective effect in human inflammatory disease states. We have evaluated the effect of chronic treatment with adenosine (100 micrograms/kg/day), on anaphylactic shock in sensitized mice and guinea pigs and on ozone-induced changes of lung function in rats, taking into account that in these models inflammatory cells and mediators are involved. Adenosine is able to inhibit the increase of wet lung weight to body weight ratio induced by ozone, and to reduce the mortality induced by anaphylactic shock in guinea pigs and mice.

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.