PMID: 8958889Nov 1, 1996Paper

Effect of adenosine infusion on oxygen induced carbon dioxide retention in severe chronic obstructive pulmonary disease

Thorax
T L GriffithsK B Saunders

Abstract

In normal subjects intravenous adenosine infusion has been shown to stimulate ventilation with a consequent fall in arterial partial pressure of carbon dioxide (Paco2), probably by an action on the carotid bodies. The objective of this study was to determine whether the increase in Paco2 seen when patients with ventilatory failure secondary to chronic obstructive pulmonary disease (COPD) are given a high concentration of oxygen to breathe might be ameliorated by an intravenous infusion of adenosine. Eight subjects with chronic stable ventilatory failure secondary to COPD were studied. Their mean (SE) forced expiratory volume in one second (FEV1) was 0.63 (0.12) 1 with forced vital capacity (FVC) of 1.63 (0.21) 1. They received continuous intravenous infusions of saline and adenosine in random order, double blind. The infusions were administered for two minutes at 20 micrograms/kg/min, increasing in increments of 20 micrograms/kg/min every two minutes to a maximum infusion rate of 80 micrograms/kg/min adenosine (or an equivalent saline infusion rate), or until side effects supervened. The infusions were continued at that rate for five minutes, after which the fractional inspired oxygen (FIO2) was raised to 0.50 during a further ...Continue Reading

References

Mar 1, 1987·British Journal of Clinical Pharmacology·P G ReidA P Smith
Nov 1, 1986·Journal of Applied Physiology·D L MaxwellJ M Hughes
Nov 1, 1985·British Journal of Clinical Pharmacology·A H Watt, P A Routledge
Dec 1, 1973·Journal of Applied Physiology·R Gelfand, C J Lambertsen
Apr 1, 1994·Human & Experimental Toxicology·I DrakeR Richards

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Citations

Sep 21, 2004·Journal of Applied Physiology·Nausherwan K BurkiLu-Yuan Lee

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